Association between Endoplasmic Reticulum Aminopeptidase-1 (ERAP-1) and Susceptibility to Ankylosing Spondylitis in Iran
Ankylosing Spondylitis (AS) is an inflammatory arthritis, which affects mainly spine and sacroiliac joints. According to recent studies, ERAP1 is the second most common candidate gene for AS susceptibility after HLA-B27. The aim of this study was to determine the association of ERAP1 gene polymo...
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Tehran University of Medical Sciences
2012-12-01
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doaj-947ceb7418ee4b83acde865c7f26809a2020-11-25T04:12:32ZengTehran University of Medical SciencesIranian Journal of Allergy, Asthma and Immunology1735-15021735-52492012-12-01114514Association between Endoplasmic Reticulum Aminopeptidase-1 (ERAP-1) and Susceptibility to Ankylosing Spondylitis in IranMahdi Mahmoudi0Ahmad Reza Jamshidi1Ali Akbar Amirzargar2Elham Farhadi3Keramat Nourijelyani4Sasan Fallahi5Mona Oraei6Sahar Noori7Mohammad Hossein Nicknam8Molecular Immunology Research Center, Tehran University of Medical Sciences, Tehran, Iran AND Rheumatology Research Center, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran AND Department of Immunology, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, IranRheumatology Research Center, Shariati Hospital, Tehran University of Medical Sciences, Tehran, IranMolecular Immunology Research Center, Tehran University of Medical Sciences, Tehran, Iran AND Department of Immunology, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, IranMolecular Immunology Research Center, Tehran University of Medical Sciences, Tehran, IranDepartment of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, IranRheumatology Research Center, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran AND Department of Rheumatology, Shafa Hospital, Kerman University of Medical Sciences, Kerman, IranDepartment of Immunology, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, IranDepartment of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, IranMolecular Immunology Research Center, Tehran University of Medical Sciences, Tehran, Iran AND Department of Immunology, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran Ankylosing Spondylitis (AS) is an inflammatory arthritis, which affects mainly spine and sacroiliac joints. According to recent studies, ERAP1 is the second most common candidate gene for AS susceptibility after HLA-B27. The aim of this study was to determine the association of ERAP1 gene polymorphisms with AS in Iranian population. The study group comprised 387 Iranian AS patients and 316 healthy controls from Iran. Using Real Time PCR allelic discrimination method, we genotyped four SNPs (rs30187, rs469876, rs13167972 and rs27434) of ERAP1. We found that rs30187 and rs27434 were significantly associated with AS in Iranian population (P=6×10-5, P=7×10-3, respectively). The rs30187 T/T genotype was associated with AS compared with C/C genotype (P=1.5×10-5). The rs27434 G/G genotype was inversely associated with AS (P=5×10-3). Two specific haplotypes including: rs30187/ rs469876/ rs13167972/ rs27434 TAAA and CAGG were associated with increased and decreased risk of AS in Iranian population, respectively. These results indicated that ERAP1 SNPs and haplotypes were associated with AS in Iranian population. https://ijaai.tums.ac.ir/index.php/ijaai/article/view/549Ankylosing SpondylitisEndoplasmic ReticulumAminopeptidase 1Single Nucleotide Polymorphism |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Mahdi Mahmoudi Ahmad Reza Jamshidi Ali Akbar Amirzargar Elham Farhadi Keramat Nourijelyani Sasan Fallahi Mona Oraei Sahar Noori Mohammad Hossein Nicknam |
spellingShingle |
Mahdi Mahmoudi Ahmad Reza Jamshidi Ali Akbar Amirzargar Elham Farhadi Keramat Nourijelyani Sasan Fallahi Mona Oraei Sahar Noori Mohammad Hossein Nicknam Association between Endoplasmic Reticulum Aminopeptidase-1 (ERAP-1) and Susceptibility to Ankylosing Spondylitis in Iran Iranian Journal of Allergy, Asthma and Immunology Ankylosing Spondylitis Endoplasmic Reticulum Aminopeptidase 1 Single Nucleotide Polymorphism |
author_facet |
Mahdi Mahmoudi Ahmad Reza Jamshidi Ali Akbar Amirzargar Elham Farhadi Keramat Nourijelyani Sasan Fallahi Mona Oraei Sahar Noori Mohammad Hossein Nicknam |
author_sort |
Mahdi Mahmoudi |
title |
Association between Endoplasmic Reticulum Aminopeptidase-1 (ERAP-1) and Susceptibility to Ankylosing Spondylitis in Iran |
title_short |
Association between Endoplasmic Reticulum Aminopeptidase-1 (ERAP-1) and Susceptibility to Ankylosing Spondylitis in Iran |
title_full |
Association between Endoplasmic Reticulum Aminopeptidase-1 (ERAP-1) and Susceptibility to Ankylosing Spondylitis in Iran |
title_fullStr |
Association between Endoplasmic Reticulum Aminopeptidase-1 (ERAP-1) and Susceptibility to Ankylosing Spondylitis in Iran |
title_full_unstemmed |
Association between Endoplasmic Reticulum Aminopeptidase-1 (ERAP-1) and Susceptibility to Ankylosing Spondylitis in Iran |
title_sort |
association between endoplasmic reticulum aminopeptidase-1 (erap-1) and susceptibility to ankylosing spondylitis in iran |
publisher |
Tehran University of Medical Sciences |
series |
Iranian Journal of Allergy, Asthma and Immunology |
issn |
1735-1502 1735-5249 |
publishDate |
2012-12-01 |
description |
Ankylosing Spondylitis (AS) is an inflammatory arthritis, which affects mainly spine and sacroiliac joints. According to recent studies, ERAP1 is the second most common candidate gene for AS susceptibility after HLA-B27. The aim of this study was to determine the association of ERAP1 gene polymorphisms with AS in Iranian population.
The study group comprised 387 Iranian AS patients and 316 healthy controls from Iran.
Using Real Time PCR allelic discrimination method, we genotyped four SNPs (rs30187, rs469876, rs13167972 and rs27434) of ERAP1.
We found that rs30187 and rs27434 were significantly associated with AS in Iranian population (P=6×10-5, P=7×10-3, respectively). The rs30187 T/T genotype was associated with AS compared with C/C genotype (P=1.5×10-5). The rs27434 G/G genotype was inversely associated with AS (P=5×10-3). Two specific haplotypes including: rs30187/ rs469876/ rs13167972/ rs27434 TAAA and CAGG were associated with increased and decreased risk of AS in Iranian population, respectively.
These results indicated that ERAP1 SNPs and haplotypes were associated with AS in Iranian population.
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topic |
Ankylosing Spondylitis Endoplasmic Reticulum Aminopeptidase 1 Single Nucleotide Polymorphism |
url |
https://ijaai.tums.ac.ir/index.php/ijaai/article/view/549 |
work_keys_str_mv |
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