Ebolavirus is internalized into host cells via macropinocytosis in a viral glycoprotein-dependent manner.
Ebolavirus (EBOV) is an enveloped, single-stranded, negative-sense RNA virus that causes severe hemorrhagic fever with mortality rates of up to 90% in humans and nonhuman primates. Previous studies suggest roles for clathrin- or caveolae-mediated endocytosis in EBOV entry; however, ebolavirus virion...
Main Authors: | Asuka Nanbo, Masaki Imai, Shinji Watanabe, Takeshi Noda, Kei Takahashi, Gabriele Neumann, Peter Halfmann, Yoshihiro Kawaoka |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2010-09-01
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Series: | PLoS Pathogens |
Online Access: | http://europepmc.org/articles/PMC2944813?pdf=render |
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