Populene D Analogues: Design, Concise Synthesis and Antiproliferative Activity
An efficient and concise synthesis of nine populene D analogues was performed using an iodine-catalyzed Prins cyclization as the key transformation. The antiproliferative activity of these new pyrans against several cancer cell lines was then investigated. Among them, an isochromene with moderate ac...
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| Format: | Article |
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MDPI AG
2012-08-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/17/8/9621 |
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doaj-9484a12b3f8e4f00be0cef79a09d5e5d2020-11-25T02:40:04ZengMDPI AGMolecules1420-30492012-08-011789621963010.3390/molecules17089621Populene D Analogues: Design, Concise Synthesis and Antiproliferative ActivityKachi R. Kishore Kumar ReddyGiovanna B. LongatoJoão E. de CarvalhoAna L. T. G. RuizLuiz F. Silva, Jr.An efficient and concise synthesis of nine populene D analogues was performed using an iodine-catalyzed Prins cyclization as the key transformation. The antiproliferative activity of these new pyrans against several cancer cell lines was then investigated. Among them, an isochromene with moderate activity (mean logGI<sub>50</sub> = 0.91) was found. Additionally, compounds with selectivity toward the tumor cell lines NCI-ADR/RES, OVCAR-3, and HT29 were discovered.http://www.mdpi.com/1420-3049/17/8/9621osochromenepyransPrins cyclizationiodineantiproliferativecancer |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Kachi R. Kishore Kumar Reddy Giovanna B. Longato João E. de Carvalho Ana L. T. G. Ruiz Luiz F. Silva, Jr. |
| spellingShingle |
Kachi R. Kishore Kumar Reddy Giovanna B. Longato João E. de Carvalho Ana L. T. G. Ruiz Luiz F. Silva, Jr. Populene D Analogues: Design, Concise Synthesis and Antiproliferative Activity Molecules osochromene pyrans Prins cyclization iodine antiproliferative cancer |
| author_facet |
Kachi R. Kishore Kumar Reddy Giovanna B. Longato João E. de Carvalho Ana L. T. G. Ruiz Luiz F. Silva, Jr. |
| author_sort |
Kachi R. Kishore Kumar Reddy |
| title |
Populene D Analogues: Design, Concise Synthesis and Antiproliferative Activity |
| title_short |
Populene D Analogues: Design, Concise Synthesis and Antiproliferative Activity |
| title_full |
Populene D Analogues: Design, Concise Synthesis and Antiproliferative Activity |
| title_fullStr |
Populene D Analogues: Design, Concise Synthesis and Antiproliferative Activity |
| title_full_unstemmed |
Populene D Analogues: Design, Concise Synthesis and Antiproliferative Activity |
| title_sort |
populene d analogues: design, concise synthesis and antiproliferative activity |
| publisher |
MDPI AG |
| series |
Molecules |
| issn |
1420-3049 |
| publishDate |
2012-08-01 |
| description |
An efficient and concise synthesis of nine populene D analogues was performed using an iodine-catalyzed Prins cyclization as the key transformation. The antiproliferative activity of these new pyrans against several cancer cell lines was then investigated. Among them, an isochromene with moderate activity (mean logGI<sub>50</sub> = 0.91) was found. Additionally, compounds with selectivity toward the tumor cell lines NCI-ADR/RES, OVCAR-3, and HT29 were discovered. |
| topic |
osochromene pyrans Prins cyclization iodine antiproliferative cancer |
| url |
http://www.mdpi.com/1420-3049/17/8/9621 |
| work_keys_str_mv |
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