Predicting important residues and interaction pathways in proteins using Gaussian Network Model: binding and stability of HLA proteins.
A statistical thermodynamics approach is proposed to determine structurally and functionally important residues in native proteins that are involved in energy exchange with a ligand and other residues along an interaction pathway. The structure-function relationships, ligand binding and allosteric a...
Main Authors: | Turkan Haliloglu, Ahmet Gul, Burak Erman |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2010-01-01
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Series: | PLoS Computational Biology |
Online Access: | http://europepmc.org/articles/PMC2900293?pdf=render |
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