(1 →3)- β -D-Glucan and endotoxin modulate immune response to inhaled allergen

• Main Authors: R. Rylander, P. G. Holt
• Format: Article
• Language: English
• Published: Hindawi Limited 1998-01-01
• Series: Mediators of Inflammation
• Subjects: (1→3)β-D-glucan; Endotoxin; T-cells; Eosinophils; Inflammation.
• Online Access: http://dx.doi.org/10.1080/09629359891252

Exposure to dust may involve co-exposure to agents which are allergens, together with those which are pro-inflamm atory. To study the effects of such a coexposure, the humoral and inflammatory responses were studied in guinea pigs inhaling the T-cell dependent antigen ovalbumin (OVA) and the inflammatory agents (1→3)-β -D-glucan and lipopolysaccharide (LPS). The effects were evaluated as inflammatory cells in the lung and serum antibodies to OVA. LPS caused a stimulation of the OVA-induced antibody production which was abolished by simultaneous exposure to (1→3)-β-D-glucan. An increase of eosinophils after OVA exposure was decreased by coexposure to (1→3)-β-D-glucan. The results demonstrate a complex interaction between adaptive and innate immune mechanisms in the lung, determined by exposure to common contaminants in airborne dust.