Correlation between interleukin-28 gene polymorphism with interleukin-28 cytokine levels and viral genotypes among HCV patients in Yazd, Iran

• Main Authors: Mansour Moghimi, Forough Tavakoli, Masoud Doosti, Abbas Ahmadi-Vasmehjani, Mohsen Akhondi-Meybodi
• Format: Article
• Language: English
• Published: BMC 2019-09-01
• Series: BMC Research Notes
• Subjects: Polymorphism; Hepatitis C; IL-28B genotype; Yazd
• Online Access: http://link.springer.com/article/10.1186/s13104-019-4651-z

Abstract Objectives Recent studies using genome-wide association studies (GWAS) have shown the strong association between polymorphisms near the interleukin-28B (IL-28B) gene and spontaneous clearance of hepatitis C virus (HCV). The present study was designed to evaluate the association of interleukin-28 gene polymorphism with interleukin-28 cytokine levels in different viral genotypes among HCV patients in Yazd, Iran. Result The most prevalent genotype in chronic cases was genotype 3a, and the lowest one was 2/3a. There were statistically significant differences in genotype frequency between the two studied groups for IL-28B rs12979860C/T. The frequency of CC genotype of IL-28B at rs12979860 SNP was higher in spontaneously cleared patients in comparison with chronic HCV patients. Significant association was found when serum levels of IL28B were compared to various IL-28 genotypes. There was a significant difference between IL-28 polymorphism and HCV genotypes (p = 0.003).