Spectral signature and behavioral consequence of spontaneous shifts of pupil-linked arousal in human
Arousal levels perpetually rise and fall spontaneously. How markers of arousal—pupil size and frequency content of brain activity—relate to each other and influence behavior in humans is poorly understood. We simultaneously monitored magnetoencephalography and pupil in healthy volunteers at rest and...
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doaj-949ea3e0c86c43449831ee41a2aa73d82021-10-01T10:17:56ZengeLife Sciences Publications LtdeLife2050-084X2021-08-011010.7554/eLife.68265Spectral signature and behavioral consequence of spontaneous shifts of pupil-linked arousal in humanElla Podvalny0https://orcid.org/0000-0002-6810-2770Leana E King1Biyu J He2https://orcid.org/0000-0003-1549-1351Neuroscience Institute, New York University School of Medicine, New York, United StatesNeuroscience Institute, New York University School of Medicine, New York, United StatesNeuroscience Institute, New York University School of Medicine, New York, United States; Departments of Neurology, Neuroscience & Physiology, and Radiology, New York University School of Medicine, New York, United StatesArousal levels perpetually rise and fall spontaneously. How markers of arousal—pupil size and frequency content of brain activity—relate to each other and influence behavior in humans is poorly understood. We simultaneously monitored magnetoencephalography and pupil in healthy volunteers at rest and during a visual perceptual decision-making task. Spontaneously varying pupil size correlates with power of brain activity in most frequency bands across large-scale resting state cortical networks. Pupil size recorded at prestimulus baseline correlates with subsequent shifts in detection bias (c) and sensitivity (d’). When dissociated from pupil-linked state, prestimulus spectral power of resting state networks still predicts perceptual behavior. Fast spontaneous pupil constriction and dilation correlate with large-scale brain activity as well but not perceptual behavior. Our results illuminate the relation between central and peripheral arousal markers and their respective roles in human perceptual decision-making.https://elifesciences.org/articles/68265spontaneous activityelectrophysiological arousalpupil-linked arousalperceptual decision-makingsignal detection theory |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ella Podvalny Leana E King Biyu J He |
spellingShingle |
Ella Podvalny Leana E King Biyu J He Spectral signature and behavioral consequence of spontaneous shifts of pupil-linked arousal in human eLife spontaneous activity electrophysiological arousal pupil-linked arousal perceptual decision-making signal detection theory |
author_facet |
Ella Podvalny Leana E King Biyu J He |
author_sort |
Ella Podvalny |
title |
Spectral signature and behavioral consequence of spontaneous shifts of pupil-linked arousal in human |
title_short |
Spectral signature and behavioral consequence of spontaneous shifts of pupil-linked arousal in human |
title_full |
Spectral signature and behavioral consequence of spontaneous shifts of pupil-linked arousal in human |
title_fullStr |
Spectral signature and behavioral consequence of spontaneous shifts of pupil-linked arousal in human |
title_full_unstemmed |
Spectral signature and behavioral consequence of spontaneous shifts of pupil-linked arousal in human |
title_sort |
spectral signature and behavioral consequence of spontaneous shifts of pupil-linked arousal in human |
publisher |
eLife Sciences Publications Ltd |
series |
eLife |
issn |
2050-084X |
publishDate |
2021-08-01 |
description |
Arousal levels perpetually rise and fall spontaneously. How markers of arousal—pupil size and frequency content of brain activity—relate to each other and influence behavior in humans is poorly understood. We simultaneously monitored magnetoencephalography and pupil in healthy volunteers at rest and during a visual perceptual decision-making task. Spontaneously varying pupil size correlates with power of brain activity in most frequency bands across large-scale resting state cortical networks. Pupil size recorded at prestimulus baseline correlates with subsequent shifts in detection bias (c) and sensitivity (d’). When dissociated from pupil-linked state, prestimulus spectral power of resting state networks still predicts perceptual behavior. Fast spontaneous pupil constriction and dilation correlate with large-scale brain activity as well but not perceptual behavior. Our results illuminate the relation between central and peripheral arousal markers and their respective roles in human perceptual decision-making. |
topic |
spontaneous activity electrophysiological arousal pupil-linked arousal perceptual decision-making signal detection theory |
url |
https://elifesciences.org/articles/68265 |
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