Increased Lung Expression of Anti-Angiogenic Factors in Down Syndrome: Potential Role in Abnormal Lung Vascular Growth and the Risk for Pulmonary Hypertension.
Infants with Down syndrome (DS) or Trisomy 21, are at high risk for developing pulmonary arterial hypertension (PAH), but mechanisms that increase susceptibility are poorly understood. Laboratory studies have shown that early disruption of angiogenesis during development impairs vascular and alveola...
Main Authors: | Csaba Galambos, Angela D Minic, Douglas Bush, Dominique Nguyen, Blair Dodson, Gregory Seedorf, Steven H Abman |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2016-01-01
|
Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC4972384?pdf=render |
Similar Items
-
Angiogenic profile identifies pulmonary hypertension in children with Down syndrome
by: Douglas Bush, et al.
Published: (2019-08-01) -
Antenatal Endotoxin Impairs Lung Mechanics and Increases Sensitivity to Ventilator-Induced Lung Injury in Newborn Rat Pups
by: Erica W. Mandell, et al.
Published: (2021-01-01) -
Abnormal Chest Radiograph Due to a Common Lung Finding in Down Syndrome
by: Devi A. Manuel, et al.
Published: (2016-01-01) -
Heterogeneous response of endothelial cells to insulin-like growth factor 1 treatment is explained by spatially clustered sub-populations
by: Christina Kim, et al.
Published: (2019-11-01) -
Detection and significance of angiogenic factors and vascular endothelial function in patients with hypertensive retinopathy of pregnancy
by: Xing-Li Zhou, et al.
Published: (2018-08-01)