Compatible Stability and Aerosol Characteristics of Atrovent<sup>®</sup> (Ipratropium Bromide) Mixed with Salbutamol Sulfate, Terbutaline Sulfate, Budesonide, and Acetylcysteine
(1) Background: It is common practice in the treatment of respiratory diseases to mix different inhalation solutions for simultaneous inhalation. At present, a small number of studies have been published that evaluate the physicochemical compatibility and aerosol characteristics of different inhalat...
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doaj-949fba86670e400eb0fb6e98c575512e2020-11-25T03:30:27ZengMDPI AGPharmaceutics1999-49232020-08-011277677610.3390/pharmaceutics12080776Compatible Stability and Aerosol Characteristics of Atrovent<sup>®</sup> (Ipratropium Bromide) Mixed with Salbutamol Sulfate, Terbutaline Sulfate, Budesonide, and AcetylcysteineYiting Chen0Shilin Du1Zhirui Zhang2Wenxiu He3Enhao Lu4Rui Wang5Xianyi Sha6Yan Ma7Key Laboratory of Smart Drug Delivery, Ministry of Education, School of Pharmacy, Fudan University, Shanghai 201203, ChinaDepartment of Emergency Medicine, Zhongshan Hospital, Fudan University, Shanghai 200032, ChinaKey Laboratory of Smart Drug Delivery, Ministry of Education, School of Pharmacy, Fudan University, Shanghai 201203, ChinaKey Laboratory of Smart Drug Delivery, Ministry of Education, School of Pharmacy, Fudan University, Shanghai 201203, ChinaKey Laboratory of Smart Drug Delivery, Ministry of Education, School of Pharmacy, Fudan University, Shanghai 201203, ChinaKey Laboratory of Smart Drug Delivery, Ministry of Education, School of Pharmacy, Fudan University, Shanghai 201203, ChinaKey Laboratory of Smart Drug Delivery, Ministry of Education, School of Pharmacy, Fudan University, Shanghai 201203, ChinaShanghai Mental Health Center, School of Medicine, Shanghai Jiaotong University, Shanghai 200030, China(1) Background: It is common practice in the treatment of respiratory diseases to mix different inhalation solutions for simultaneous inhalation. At present, a small number of studies have been published that evaluate the physicochemical compatibility and aerosol characteristics of different inhalation medications. However, none of them studied Atrovent<sup>®</sup>. Our work aims to address the lack of studies on Atrovent<sup>®</sup>. (2) Methods: Portions of admixtures were withdrawn at certain time intervals after mixing and were tested by pH determination, osmolarity measurement, and high-performance liquid chromatography (HPLC) assay of each active ingredient as measures of physicochemical compatibility. The geometrical and aerosol particle size distribution, active drug delivery rate, and total active drug delivered were measured to characterize aerosol behaviors. (3) Results: During the testing time, no significant variation was found in the pH value, the osmotic pressure, or the active components of admixtures. With the increase in nebulization volume after mixing, fine particle dose (FPD) and total active drug delivered showed statistically significant improvements, while the active drug delivery rate decreased compared to the single-drug preparations. (4) Conclusions: These results endorse the physicochemical compatibility of Atrovent<sup>®</sup> over 1 h when mixed with other inhalation medications. Considering aerosol characteristics, simultaneous inhalation is more efficient.https://www.mdpi.com/1999-4923/12/8/776Atrovent<sup>®</sup>Ventolin<sup>®</sup>Bricanyl<sup>®</sup>Pulmicort<sup>®</sup>Fluimucil<sup>®</sup>ipratropium |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yiting Chen Shilin Du Zhirui Zhang Wenxiu He Enhao Lu Rui Wang Xianyi Sha Yan Ma |
spellingShingle |
Yiting Chen Shilin Du Zhirui Zhang Wenxiu He Enhao Lu Rui Wang Xianyi Sha Yan Ma Compatible Stability and Aerosol Characteristics of Atrovent<sup>®</sup> (Ipratropium Bromide) Mixed with Salbutamol Sulfate, Terbutaline Sulfate, Budesonide, and Acetylcysteine Pharmaceutics Atrovent<sup>®</sup> Ventolin<sup>®</sup> Bricanyl<sup>®</sup> Pulmicort<sup>®</sup> Fluimucil<sup>®</sup> ipratropium |
author_facet |
Yiting Chen Shilin Du Zhirui Zhang Wenxiu He Enhao Lu Rui Wang Xianyi Sha Yan Ma |
author_sort |
Yiting Chen |
title |
Compatible Stability and Aerosol Characteristics of Atrovent<sup>®</sup> (Ipratropium Bromide) Mixed with Salbutamol Sulfate, Terbutaline Sulfate, Budesonide, and Acetylcysteine |
title_short |
Compatible Stability and Aerosol Characteristics of Atrovent<sup>®</sup> (Ipratropium Bromide) Mixed with Salbutamol Sulfate, Terbutaline Sulfate, Budesonide, and Acetylcysteine |
title_full |
Compatible Stability and Aerosol Characteristics of Atrovent<sup>®</sup> (Ipratropium Bromide) Mixed with Salbutamol Sulfate, Terbutaline Sulfate, Budesonide, and Acetylcysteine |
title_fullStr |
Compatible Stability and Aerosol Characteristics of Atrovent<sup>®</sup> (Ipratropium Bromide) Mixed with Salbutamol Sulfate, Terbutaline Sulfate, Budesonide, and Acetylcysteine |
title_full_unstemmed |
Compatible Stability and Aerosol Characteristics of Atrovent<sup>®</sup> (Ipratropium Bromide) Mixed with Salbutamol Sulfate, Terbutaline Sulfate, Budesonide, and Acetylcysteine |
title_sort |
compatible stability and aerosol characteristics of atrovent<sup>®</sup> (ipratropium bromide) mixed with salbutamol sulfate, terbutaline sulfate, budesonide, and acetylcysteine |
publisher |
MDPI AG |
series |
Pharmaceutics |
issn |
1999-4923 |
publishDate |
2020-08-01 |
description |
(1) Background: It is common practice in the treatment of respiratory diseases to mix different inhalation solutions for simultaneous inhalation. At present, a small number of studies have been published that evaluate the physicochemical compatibility and aerosol characteristics of different inhalation medications. However, none of them studied Atrovent<sup>®</sup>. Our work aims to address the lack of studies on Atrovent<sup>®</sup>. (2) Methods: Portions of admixtures were withdrawn at certain time intervals after mixing and were tested by pH determination, osmolarity measurement, and high-performance liquid chromatography (HPLC) assay of each active ingredient as measures of physicochemical compatibility. The geometrical and aerosol particle size distribution, active drug delivery rate, and total active drug delivered were measured to characterize aerosol behaviors. (3) Results: During the testing time, no significant variation was found in the pH value, the osmotic pressure, or the active components of admixtures. With the increase in nebulization volume after mixing, fine particle dose (FPD) and total active drug delivered showed statistically significant improvements, while the active drug delivery rate decreased compared to the single-drug preparations. (4) Conclusions: These results endorse the physicochemical compatibility of Atrovent<sup>®</sup> over 1 h when mixed with other inhalation medications. Considering aerosol characteristics, simultaneous inhalation is more efficient. |
topic |
Atrovent<sup>®</sup> Ventolin<sup>®</sup> Bricanyl<sup>®</sup> Pulmicort<sup>®</sup> Fluimucil<sup>®</sup> ipratropium |
url |
https://www.mdpi.com/1999-4923/12/8/776 |
work_keys_str_mv |
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