Involvement of cytochrome P450 1A1 and glutathione S-transferase P1 polymorphisms and promoter hypermethylation in the progression of anti-tuberculosis drug-induced liver injury: a case-control study.
<h4>Background</h4>Anti-tuberculosis (anti-TB) drug-induced liver injury (ADLI) is one of the most common adverse effects associated with TB treatment. Cytochrome P450 (CYP) 1A1 and glutathione S-transferase (GST) P1 are important phase I/II metabolizing enzymes involved in drug metaboli...
Main Authors: | Lei He, Li Gao, Zhe Shi, Yuhong Li, Lingyan Zhu, Shiming Li, Peng Zhang, Guoying Zheng, Qi Ren, Yun Li, Bo Hu, Fumin Feng |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2015-01-01
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Series: | PLoS ONE |
Online Access: | https://doi.org/10.1371/journal.pone.0119481 |
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