Circulating Tumor Cells and Fibronectin 1 in the Prognosis of Nasopharyngeal Carcinoma
Objective: Nasopharyngeal carcinoma is highly endemic in Southeast China. Circulating tumor cell is an important biomarker in the prognosis of variety kinds of cancers. Overexpression of fibronectin 1 was observed in variety kinds of malignancies and may contribute to progress and metastasis of the...
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doaj-94aa5a878f82454aba642c845b67f1622020-11-25T03:24:06ZengSAGE PublishingTechnology in Cancer Research & Treatment1533-03382020-04-011910.1177/1533033820909911Circulating Tumor Cells and Fibronectin 1 in the Prognosis of Nasopharyngeal CarcinomaYing Yu BM0Zhi-Xiu Lin BM1Hai-Wen Li MM2Hai-Qing Luo MD3Dong-Hong Yang MM4He-Chao Zhou MM5Dan-Xian Jiang MD6De-Chao Zhan MM7Liu Yang MM8Xiao-Ye Liang MM9Zhong-Hua Yu MM10Zi-Hong Chen BM11 Cancer Center, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, China Department of Pharmacy, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, China Cancer Center, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, China Cancer Center, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, China Cancer Center, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, China Cancer Center, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, China Cancer Center, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, China Cancer Center, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, China Cancer Center, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, China Cancer Center, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, China Cancer Center, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, China Cancer Center, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, ChinaObjective: Nasopharyngeal carcinoma is highly endemic in Southeast China. Circulating tumor cell is an important biomarker in the prognosis of variety kinds of cancers. Overexpression of fibronectin 1 was observed in variety kinds of malignancies and may contribute to progress and metastasis of the cancers. The current study was aimed to investigate phenotypes of circulating tumor cell in nasopharyngeal carcinoma blood and fibronectin 1 expression in the circulating tumor cell, and their clinical application in predicting nasopharyngeal carcinoma prognosis. Methods: Blood samples were obtained from nasopharyngeal carcinoma patients before and after treatment. CanPatrol circulating tumor cell enrichment and RNA in situ hybridization were applied to identify circulating tumor cell and its phenotypes. Fibronectin 1 messenger RNA expression in the cells of circulating tumors was examined by messenger RNA-in situ hybridization. Results: Circulating tumor cell was not associated with tumor characteristics or lymph node metastasis. Patients with >9 circulating tumor cells or >5 mesenchymal phenotype circulating tumor cell per 5-mL blood had poorer progression-free survival ( P < .05). Multivariable analysis demonstrated that 2 or more mesenchymal phenotype circulating tumor cells with high fibronectin 1 messenger RNA expression predicted shorter progression-free survival ( P < .05). Conclusions: Circulating tumor cells with high-level fibronectin 1 expression was associated with poor survival in patients with nasopharyngeal carcinoma and could be an independent prognostic factor for nasopharyngeal carcinoma.https://doi.org/10.1177/1533033820909911 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ying Yu BM Zhi-Xiu Lin BM Hai-Wen Li MM Hai-Qing Luo MD Dong-Hong Yang MM He-Chao Zhou MM Dan-Xian Jiang MD De-Chao Zhan MM Liu Yang MM Xiao-Ye Liang MM Zhong-Hua Yu MM Zi-Hong Chen BM |
spellingShingle |
Ying Yu BM Zhi-Xiu Lin BM Hai-Wen Li MM Hai-Qing Luo MD Dong-Hong Yang MM He-Chao Zhou MM Dan-Xian Jiang MD De-Chao Zhan MM Liu Yang MM Xiao-Ye Liang MM Zhong-Hua Yu MM Zi-Hong Chen BM Circulating Tumor Cells and Fibronectin 1 in the Prognosis of Nasopharyngeal Carcinoma Technology in Cancer Research & Treatment |
author_facet |
Ying Yu BM Zhi-Xiu Lin BM Hai-Wen Li MM Hai-Qing Luo MD Dong-Hong Yang MM He-Chao Zhou MM Dan-Xian Jiang MD De-Chao Zhan MM Liu Yang MM Xiao-Ye Liang MM Zhong-Hua Yu MM Zi-Hong Chen BM |
author_sort |
Ying Yu BM |
title |
Circulating Tumor Cells and Fibronectin 1 in the Prognosis of Nasopharyngeal Carcinoma |
title_short |
Circulating Tumor Cells and Fibronectin 1 in the Prognosis of Nasopharyngeal Carcinoma |
title_full |
Circulating Tumor Cells and Fibronectin 1 in the Prognosis of Nasopharyngeal Carcinoma |
title_fullStr |
Circulating Tumor Cells and Fibronectin 1 in the Prognosis of Nasopharyngeal Carcinoma |
title_full_unstemmed |
Circulating Tumor Cells and Fibronectin 1 in the Prognosis of Nasopharyngeal Carcinoma |
title_sort |
circulating tumor cells and fibronectin 1 in the prognosis of nasopharyngeal carcinoma |
publisher |
SAGE Publishing |
series |
Technology in Cancer Research & Treatment |
issn |
1533-0338 |
publishDate |
2020-04-01 |
description |
Objective: Nasopharyngeal carcinoma is highly endemic in Southeast China. Circulating tumor cell is an important biomarker in the prognosis of variety kinds of cancers. Overexpression of fibronectin 1 was observed in variety kinds of malignancies and may contribute to progress and metastasis of the cancers. The current study was aimed to investigate phenotypes of circulating tumor cell in nasopharyngeal carcinoma blood and fibronectin 1 expression in the circulating tumor cell, and their clinical application in predicting nasopharyngeal carcinoma prognosis. Methods: Blood samples were obtained from nasopharyngeal carcinoma patients before and after treatment. CanPatrol circulating tumor cell enrichment and RNA in situ hybridization were applied to identify circulating tumor cell and its phenotypes. Fibronectin 1 messenger RNA expression in the cells of circulating tumors was examined by messenger RNA-in situ hybridization. Results: Circulating tumor cell was not associated with tumor characteristics or lymph node metastasis. Patients with >9 circulating tumor cells or >5 mesenchymal phenotype circulating tumor cell per 5-mL blood had poorer progression-free survival ( P < .05). Multivariable analysis demonstrated that 2 or more mesenchymal phenotype circulating tumor cells with high fibronectin 1 messenger RNA expression predicted shorter progression-free survival ( P < .05). Conclusions: Circulating tumor cells with high-level fibronectin 1 expression was associated with poor survival in patients with nasopharyngeal carcinoma and could be an independent prognostic factor for nasopharyngeal carcinoma. |
url |
https://doi.org/10.1177/1533033820909911 |
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