Association Between Hematological Parameters and Iron Metabolism Response After Marathon Race and ACTN3 Genotype
α-Actinin-3 (ACTN3 R577X, rs.1815739) polymorphism is a genetic variation that shows the most consistent influence on metabolic pathway and muscle phenotype. XX genotype is associated with higher metabolic efficiency of skeletal muscle; however, the role of ACTN3 polymorphism in oxygen transport and...
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Frontiers Media S.A.
2019-06-01
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Series: | Frontiers in Physiology |
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Online Access: | https://www.frontiersin.org/article/10.3389/fphys.2019.00697/full |
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doaj-94ab2538bfaa40d990751483d6263f84 |
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record_format |
Article |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ana Paula Renno Sierra Ana Paula Renno Sierra Rodrigo Assunção Oliveira Elton Dias Silva Giscard Humberto Oliveira Lima Giscard Humberto Oliveira Lima Marino Pereira Benetti Maria Augusta Pedanti Kiss Carlos Anibal Sierra Nabil Ghorayeb Jane T. Seto João Bosco Pesquero Maria Fernanda Cury-Boaventura |
spellingShingle |
Ana Paula Renno Sierra Ana Paula Renno Sierra Rodrigo Assunção Oliveira Elton Dias Silva Giscard Humberto Oliveira Lima Giscard Humberto Oliveira Lima Marino Pereira Benetti Maria Augusta Pedanti Kiss Carlos Anibal Sierra Nabil Ghorayeb Jane T. Seto João Bosco Pesquero Maria Fernanda Cury-Boaventura Association Between Hematological Parameters and Iron Metabolism Response After Marathon Race and ACTN3 Genotype Frontiers in Physiology long-distance exercise iron metabolism polymorphism hematological parameters actinin-3 |
author_facet |
Ana Paula Renno Sierra Ana Paula Renno Sierra Rodrigo Assunção Oliveira Elton Dias Silva Giscard Humberto Oliveira Lima Giscard Humberto Oliveira Lima Marino Pereira Benetti Maria Augusta Pedanti Kiss Carlos Anibal Sierra Nabil Ghorayeb Jane T. Seto João Bosco Pesquero Maria Fernanda Cury-Boaventura |
author_sort |
Ana Paula Renno Sierra |
title |
Association Between Hematological Parameters and Iron Metabolism Response After Marathon Race and ACTN3 Genotype |
title_short |
Association Between Hematological Parameters and Iron Metabolism Response After Marathon Race and ACTN3 Genotype |
title_full |
Association Between Hematological Parameters and Iron Metabolism Response After Marathon Race and ACTN3 Genotype |
title_fullStr |
Association Between Hematological Parameters and Iron Metabolism Response After Marathon Race and ACTN3 Genotype |
title_full_unstemmed |
Association Between Hematological Parameters and Iron Metabolism Response After Marathon Race and ACTN3 Genotype |
title_sort |
association between hematological parameters and iron metabolism response after marathon race and actn3 genotype |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Physiology |
issn |
1664-042X |
publishDate |
2019-06-01 |
description |
α-Actinin-3 (ACTN3 R577X, rs.1815739) polymorphism is a genetic variation that shows the most consistent influence on metabolic pathway and muscle phenotype. XX genotype is associated with higher metabolic efficiency of skeletal muscle; however, the role of ACTN3 polymorphism in oxygen transport and utilization system has not yet been investigated. Therefore, the aim of this study was to determine the influence of ACTN3 polymorphisms on hematological and iron metabolism response induced by marathon race. Eighty-one Brazilian amateur male endurance runners participated in the study. Blood samples and urine were collected before; immediately after; and 1, 3, and 15 days after the marathon race. Urine, hematological parameters, iron metabolism, and ACTN3 genotyping analyses were performed. The marathon race induced a decrease in erythrocytes, Hb, and Ht, and an increase in hematuria, creatinine, myoglobin, red cell distribution width, mean corpuscular hemoglobin concentration, mean corpuscular hemoglobin, direct and indirect bilirubin and erythropoietin. Moreover, an elevation immediately or 1 day after the marathon race follows a reduction 3 or 15 days after the marathon race were observed on transferrin saturation and iron and transferrin levels. Hematological parameters and iron metabolism changes induced by marathon race were not observed in XX genotypes. Hematuria and decreased erythrocytes, Hb, Ht, and iron and transferrin levels were observed only in RR and/or RX genotypes but not in XX genotypes. The percentage of runners with hematuria, leukocyturia, iron deficiency, creatinine, myoglobin, and bilirubin imbalance was higher in RR compared to XX genotypes. ACTN3 polymorphism is associated with iron metabolism and hematological responses after endurance exercise. Despite these results being based on a small sample, they highlight a protective role of the XX genotype on hematological and renal changes induced by long-distance exercise. Therefore, these findings should be further replicated. |
topic |
long-distance exercise iron metabolism polymorphism hematological parameters actinin-3 |
url |
https://www.frontiersin.org/article/10.3389/fphys.2019.00697/full |
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doaj-94ab2538bfaa40d990751483d6263f842020-11-24T20:43:06ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2019-06-011010.3389/fphys.2019.00697451431Association Between Hematological Parameters and Iron Metabolism Response After Marathon Race and ACTN3 GenotypeAna Paula Renno Sierra0Ana Paula Renno Sierra1Rodrigo Assunção Oliveira2Elton Dias Silva3Giscard Humberto Oliveira Lima4Giscard Humberto Oliveira Lima5Marino Pereira Benetti6Maria Augusta Pedanti Kiss7Carlos Anibal Sierra8Nabil Ghorayeb9Jane T. Seto10João Bosco Pesquero11Maria Fernanda Cury-Boaventura12Department of Biodynamics of Human Movements, School of Physical Education and Sports, University of São Paulo, São Paulo, BrazilSports Cardiology Department, Dante Pazzanese Institute of Cardiology, São Paulo, BrazilDepartment of Interdisciplinary in Health Sciences, Institute of Physical Activity and Sports Sciences, Cruzeiro do Sul University, São Paulo, BrazilDepartment of Biophysics, Federal University of São Paulo, São Paulo, BrazilDepartment of Biophysics, Federal University of São Paulo, São Paulo, BrazilDepartment of Movement, Human and Health Sciences, Program of Human Movement and Sport Sciences, University of Rome “Foro Italico”, Rome, ItalyDepartment of Biodynamics of Human Movements, School of Physical Education and Sports, University of São Paulo, São Paulo, BrazilDepartment of Biodynamics of Human Movements, School of Physical Education and Sports, University of São Paulo, São Paulo, BrazilSports Cardiology Department, Dante Pazzanese Institute of Cardiology, São Paulo, BrazilSports Cardiology Department, Dante Pazzanese Institute of Cardiology, São Paulo, BrazilNeuromuscular Research, Murdoch Children’s Research Institute, Melbourne, VIC, AustraliaDepartment of Biophysics, Federal University of São Paulo, São Paulo, BrazilDepartment of Interdisciplinary in Health Sciences, Institute of Physical Activity and Sports Sciences, Cruzeiro do Sul University, São Paulo, Brazilα-Actinin-3 (ACTN3 R577X, rs.1815739) polymorphism is a genetic variation that shows the most consistent influence on metabolic pathway and muscle phenotype. XX genotype is associated with higher metabolic efficiency of skeletal muscle; however, the role of ACTN3 polymorphism in oxygen transport and utilization system has not yet been investigated. Therefore, the aim of this study was to determine the influence of ACTN3 polymorphisms on hematological and iron metabolism response induced by marathon race. Eighty-one Brazilian amateur male endurance runners participated in the study. Blood samples and urine were collected before; immediately after; and 1, 3, and 15 days after the marathon race. Urine, hematological parameters, iron metabolism, and ACTN3 genotyping analyses were performed. The marathon race induced a decrease in erythrocytes, Hb, and Ht, and an increase in hematuria, creatinine, myoglobin, red cell distribution width, mean corpuscular hemoglobin concentration, mean corpuscular hemoglobin, direct and indirect bilirubin and erythropoietin. Moreover, an elevation immediately or 1 day after the marathon race follows a reduction 3 or 15 days after the marathon race were observed on transferrin saturation and iron and transferrin levels. Hematological parameters and iron metabolism changes induced by marathon race were not observed in XX genotypes. Hematuria and decreased erythrocytes, Hb, Ht, and iron and transferrin levels were observed only in RR and/or RX genotypes but not in XX genotypes. The percentage of runners with hematuria, leukocyturia, iron deficiency, creatinine, myoglobin, and bilirubin imbalance was higher in RR compared to XX genotypes. ACTN3 polymorphism is associated with iron metabolism and hematological responses after endurance exercise. Despite these results being based on a small sample, they highlight a protective role of the XX genotype on hematological and renal changes induced by long-distance exercise. Therefore, these findings should be further replicated.https://www.frontiersin.org/article/10.3389/fphys.2019.00697/fulllong-distance exerciseiron metabolismpolymorphismhematological parametersactinin-3 |