Liver X Receptors and Male (In)fertility
Liver X receptors (LXRs) are ligand-dependent transcription factors acting as ‘cholesterol sensors’ to regulate lipid homeostasis in cells. The two isoforms, LXRα (NR1H3) and LXRβ (NR1H2), are differentially expressed, with the former expressed predominantly in...
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doaj-94ad50b59a5b4cebbf1b786a3cab43412020-11-25T01:33:52ZengMDPI AGInternational Journal of Molecular Sciences1422-00672019-10-012021537910.3390/ijms20215379ijms20215379Liver X Receptors and Male (In)fertilitySheba Jarvis0Catherine Williamson1Charlotte L Bevan2Department of Surgery and Cancer, Imperial College London, London W12 0NN, UKDepartment of Women and Children’s Health, King’s College London, London SE1 9UL, UKDepartment of Surgery and Cancer, Imperial College London, London W12 0NN, UKLiver X receptors (LXRs) are ligand-dependent transcription factors acting as ‘cholesterol sensors’ to regulate lipid homeostasis in cells. The two isoforms, LXRα (NR1H3) and LXRβ (NR1H2), are differentially expressed, with the former expressed predominantly in metabolically active tissues and the latter more ubiquitously. Both are activated by oxidised cholesterol metabolites, endogenously produced oxysterols. LXRs have important roles in lipid metabolism and inflammation, plus a number of newly emerging roles. They are implicated in regulating lipid balance in normal male reproductive function and may provide a link between male infertility and lipid disorders and/or obesity. Studies from Lxr knockout mouse models provide compelling evidence to support this. More recently published data suggest distinct and overlapping roles of the LXR isoforms in the testis and recent evidence of a role for LXRs in human male fertility. This review summarises the current literature and explores the likely link between LXR, lipid metabolism and male fertility as part of a special issue on Liver X receptors in International Journal of Molecular Sciences.https://www.mdpi.com/1422-0067/20/21/5379liver x receptorstestisinfertilitysteroidogenesisoxysterols |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Sheba Jarvis Catherine Williamson Charlotte L Bevan |
spellingShingle |
Sheba Jarvis Catherine Williamson Charlotte L Bevan Liver X Receptors and Male (In)fertility International Journal of Molecular Sciences liver x receptors testis infertility steroidogenesis oxysterols |
author_facet |
Sheba Jarvis Catherine Williamson Charlotte L Bevan |
author_sort |
Sheba Jarvis |
title |
Liver X Receptors and Male (In)fertility |
title_short |
Liver X Receptors and Male (In)fertility |
title_full |
Liver X Receptors and Male (In)fertility |
title_fullStr |
Liver X Receptors and Male (In)fertility |
title_full_unstemmed |
Liver X Receptors and Male (In)fertility |
title_sort |
liver x receptors and male (in)fertility |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1422-0067 |
publishDate |
2019-10-01 |
description |
Liver X receptors (LXRs) are ligand-dependent transcription factors acting as ‘cholesterol sensors’ to regulate lipid homeostasis in cells. The two isoforms, LXRα (NR1H3) and LXRβ (NR1H2), are differentially expressed, with the former expressed predominantly in metabolically active tissues and the latter more ubiquitously. Both are activated by oxidised cholesterol metabolites, endogenously produced oxysterols. LXRs have important roles in lipid metabolism and inflammation, plus a number of newly emerging roles. They are implicated in regulating lipid balance in normal male reproductive function and may provide a link between male infertility and lipid disorders and/or obesity. Studies from Lxr knockout mouse models provide compelling evidence to support this. More recently published data suggest distinct and overlapping roles of the LXR isoforms in the testis and recent evidence of a role for LXRs in human male fertility. This review summarises the current literature and explores the likely link between LXR, lipid metabolism and male fertility as part of a special issue on Liver X receptors in International Journal of Molecular Sciences. |
topic |
liver x receptors testis infertility steroidogenesis oxysterols |
url |
https://www.mdpi.com/1422-0067/20/21/5379 |
work_keys_str_mv |
AT shebajarvis liverxreceptorsandmaleinfertility AT catherinewilliamson liverxreceptorsandmaleinfertility AT charlottelbevan liverxreceptorsandmaleinfertility |
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