Limited Impact of Human Cytomegalovirus Infection in African Infants on Vaccine-Specific Responses Following Diphtheria-Tetanus-Pertussis and Measles Vaccination

Limited Impact of Human Cytomegalovirus Infection in African Infants on Vaccine-Specific Responses Following Diphtheria-Tetanus-Pertussis and Measles Vaccination

Human cytomegalovirus (HCMV) infection has a profound effect on the human immune system, causing massive clonal expansion of CD8, and to a lesser extend CD4 T cells. The few human trials that have explored the effect of HCMV infection on responses to vaccination are conflicting, with some studies su...

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Bibliographic Details
Main Authors: Momodou Cox, Jane U. Adetifa, Fatou Noho-Konteh, Jainaba Njie-Jobe, Lady C. Sanyang, Abdoulie Drammeh, Magdalena Plebanski, Hilton C. Whittle, Sarah L. Rowland-Jones, Iain Robertson, Katie L. Flanagan
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Immunology
Subjects:
human cytomegalovirus
human infants
measles vaccination
diphtheria-tetanus-pertussis (DTwP) vaccination
vaccine responses
antibodies
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01083/full

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