Reinforcement determines the timing dependence of corticostriatal synaptic plasticity in vivo

Reinforcement determines the timing dependence of corticostriatal synaptic plasticity in vivo

Spike timing dependent plasticity (STDP) has been studied extensively in slices but whether such pairings can induce plasticity in vivo is not known. Here the authors report an experimental paradigm that achieves bidirectional corticostriatal STDP in vivo through modulation by behaviourally relevant...

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Bibliographic Details
Main Authors: Simon D. Fisher, Paul B. Robertson, Melony J. Black, Peter Redgrave, Mark A. Sagar, Wickliffe C. Abraham, John N.J. Reynolds
Format: Article
Language:English
Published: Nature Publishing Group 2017-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-00394-x
Description
Summary:Spike timing dependent plasticity (STDP) has been studied extensively in slices but whether such pairings can induce plasticity in vivo is not known. Here the authors report an experimental paradigm that achieves bidirectional corticostriatal STDP in vivo through modulation by behaviourally relevant reinforcement signals, mediated by dopamine and adenosine signaling.
ISSN:2041-1723

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