Reverse Chemical Genetics: Comprehensive Fitness Profiling Reveals the Spectrum of Drug Target Interactions.
The emergence and prevalence of drug resistance demands streamlined strategies to identify drug resistant variants in a fast, systematic and cost-effective way. Methods commonly used to understand and predict drug resistance rely on limited clinical studies from patients who are refractory to drugs...
Main Authors: | Lai H Wong, Sunita Sinha, Julien R Bergeron, Joseph C Mellor, Guri Giaever, Patrick Flaherty, Corey Nislow |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2016-09-01
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Series: | PLoS Genetics |
Online Access: | http://europepmc.org/articles/PMC5010250?pdf=render |
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