Talaromyces marneffei promotes M2-like polarization of human macrophages by downregulating SOCS3 expression and activating the TLR9 pathway

Talaromyces marneffei promotes M2-like polarization of human macrophages by downregulating SOCS3 expression and activating the TLR9 pathway

Little is known about how Talaromyces marneffei, a thermally dimorphic fungus that causes substantial morbidity and mortality in Southeast Asia, evades the human immune system. Polarization of macrophages into fungal-inhibiting M1-like and fungal-promoting M2-like types has been shown to play an imp...

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Bibliographic Details
Main Authors: Wudi Wei, Chuanyi Ning, Jiegang Huang, Gang Wang, Jingzhen Lai, Jing Han, Jinhao He, Hong Zhang, Bingyu Liang, Yanyan Liao, Thuy Le, Qiang Luo, Zhen Li, Junjun Jiang, Li Ye, Hao Liang
Format: Article
Language:English
Published: Taylor & Francis Group 2021-01-01
Series:Virulence
Subjects:
talaromyces marneffei
macrophages
m2 polarization
socs3
tlr9 pathway
Online Access:http://dx.doi.org/10.1080/21505594.2021.1958470

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