Risk of Colorectal Cancer in Patients With Attention-Deficit Hyperactivity Disorder: A Nationwide, Population-Based Cohort Study
Background: The association between attention-deficit hypersensitivity disorder (ADHD) and the risk of developing colorectal cancer (CRC) is, as yet, to be investigated, and thus, we have conducted this nationwide, cohort study to examine the association in patients from Taiwan.Methods: In this stud...
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Frontiers Media S.A.
2021-02-01
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Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2021.537137/full |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Je-Ming Hu Je-Ming Hu Je-Ming Hu Chia-Cheng Lee Chia-Cheng Lee Chia-Cheng Lee Tzu-Chiao Lin Chi-Hsiang Chung Chi-Hsiang Chung Chi-Hsiang Chung Chao-Yang Chen Pi-Kai Chang Cheng-Wen Hsiao Chien-An Sun Chien-An Sun Nian-Sheng Tzeng Nian-Sheng Tzeng Wu-Chien Chien Wu-Chien Chien Wu-Chien Chien Wu-Chien Chien |
spellingShingle |
Je-Ming Hu Je-Ming Hu Je-Ming Hu Chia-Cheng Lee Chia-Cheng Lee Chia-Cheng Lee Tzu-Chiao Lin Chi-Hsiang Chung Chi-Hsiang Chung Chi-Hsiang Chung Chao-Yang Chen Pi-Kai Chang Cheng-Wen Hsiao Chien-An Sun Chien-An Sun Nian-Sheng Tzeng Nian-Sheng Tzeng Wu-Chien Chien Wu-Chien Chien Wu-Chien Chien Wu-Chien Chien Risk of Colorectal Cancer in Patients With Attention-Deficit Hyperactivity Disorder: A Nationwide, Population-Based Cohort Study Frontiers in Psychiatry attention-deficit hyperactivity disorder colorectal cancer retrospective cohort study National Health Insurance Research Database Longitudinal Health Insurance Database |
author_facet |
Je-Ming Hu Je-Ming Hu Je-Ming Hu Chia-Cheng Lee Chia-Cheng Lee Chia-Cheng Lee Tzu-Chiao Lin Chi-Hsiang Chung Chi-Hsiang Chung Chi-Hsiang Chung Chao-Yang Chen Pi-Kai Chang Cheng-Wen Hsiao Chien-An Sun Chien-An Sun Nian-Sheng Tzeng Nian-Sheng Tzeng Wu-Chien Chien Wu-Chien Chien Wu-Chien Chien Wu-Chien Chien |
author_sort |
Je-Ming Hu |
title |
Risk of Colorectal Cancer in Patients With Attention-Deficit Hyperactivity Disorder: A Nationwide, Population-Based Cohort Study |
title_short |
Risk of Colorectal Cancer in Patients With Attention-Deficit Hyperactivity Disorder: A Nationwide, Population-Based Cohort Study |
title_full |
Risk of Colorectal Cancer in Patients With Attention-Deficit Hyperactivity Disorder: A Nationwide, Population-Based Cohort Study |
title_fullStr |
Risk of Colorectal Cancer in Patients With Attention-Deficit Hyperactivity Disorder: A Nationwide, Population-Based Cohort Study |
title_full_unstemmed |
Risk of Colorectal Cancer in Patients With Attention-Deficit Hyperactivity Disorder: A Nationwide, Population-Based Cohort Study |
title_sort |
risk of colorectal cancer in patients with attention-deficit hyperactivity disorder: a nationwide, population-based cohort study |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Psychiatry |
issn |
1664-0640 |
publishDate |
2021-02-01 |
description |
Background: The association between attention-deficit hypersensitivity disorder (ADHD) and the risk of developing colorectal cancer (CRC) is, as yet, to be investigated, and thus, we have conducted this nationwide, cohort study to examine the association in patients from Taiwan.Methods: In this study, 798 individuals with newly diagnosed ADHD and 2,394 (1:3) age-, gender-, and index year- matched controls without ADHD were enrolled, between 2000 and 2013, from the Longitudinal Health Insurance Database, a subset of the National Health Insurance Research Database in Taiwan. The cumulative incidence of CRC was assessed in each cohort by the Kaplan–Meier method. The multivariate Cox proportional hazards model was used to estimate the crude, and the adjusted hazards ratios (HRs) with 95% confidence intervals (CIs), was conducted to estimate the association between ADHD and CRC.Results: The Kaplan–Meier analysis revealed that the cumulative incidence of CRC was significantly higher in patients with ADHD than in those without it (log rank test, p < 0.001). After adjustments for age, gender, comorbidities, and other covariates, the ADHD group was associated with an increased risk of CRC in comparison to the non-ADHD group (adjusted HR = 3.458, 95% CI = 1.640–7.293, p < 0.001). In addition, the usage of methylphenidate was not associated with the risk of developing CRC in patients with ADHD.Conclusion: This retrospective cohort study depicts the evidence that ADHD was associated with the increased risk of CRC. Further studies are needed to confirm the association and the underlying mechanisms. |
topic |
attention-deficit hyperactivity disorder colorectal cancer retrospective cohort study National Health Insurance Research Database Longitudinal Health Insurance Database |
url |
https://www.frontiersin.org/articles/10.3389/fpsyt.2021.537137/full |
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doaj-94d8e65734544ac7ab41dfa02cc2dbde2021-02-05T05:47:03ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402021-02-011210.3389/fpsyt.2021.537137537137Risk of Colorectal Cancer in Patients With Attention-Deficit Hyperactivity Disorder: A Nationwide, Population-Based Cohort StudyJe-Ming Hu0Je-Ming Hu1Je-Ming Hu2Chia-Cheng Lee3Chia-Cheng Lee4Chia-Cheng Lee5Tzu-Chiao Lin6Chi-Hsiang Chung7Chi-Hsiang Chung8Chi-Hsiang Chung9Chao-Yang Chen10Pi-Kai Chang11Cheng-Wen Hsiao12Chien-An Sun13Chien-An Sun14Nian-Sheng Tzeng15Nian-Sheng Tzeng16Wu-Chien Chien17Wu-Chien Chien18Wu-Chien Chien19Wu-Chien Chien20Division of Colorectal Surgery, Department of surgery, Tri-Service General Hospital, School of Medicine, National Defense Medical Center, Taipei, TaiwanGraduate Institute of Medical Sciences, National Defense Medical Center, Taipei, TaiwanMedical Informatics Office, Tri-Service General Hospital, National Defense Medical Center, Taipei, TaiwanDivision of Colorectal Surgery, Department of surgery, Tri-Service General Hospital, School of Medicine, National Defense Medical Center, Taipei, TaiwanMedical Informatics Office, Tri-Service General Hospital, National Defense Medical Center, Taipei, TaiwanArtificial Intelligence Center, Tri-Service General Hospital, National Defense Medical Center, Taipei, TaiwanDivision of Colorectal Surgery, Department of surgery, Tri-Service General Hospital, School of Medicine, National Defense Medical Center, Taipei, TaiwanSchool of Public Health, National Defense Medical Center, Taipei, TaiwanDepartment of Medical Research, Tri-Service General Hospital, National Defense Medical Center, Taipei, TaiwanTaiwanese Injury Prevention and Safety Promotion Association, Taipei, TaiwanDivision of Colorectal Surgery, Department of surgery, Tri-Service General Hospital, School of Medicine, National Defense Medical Center, Taipei, TaiwanDivision of Colorectal Surgery, Department of surgery, Tri-Service General Hospital, School of Medicine, National Defense Medical Center, Taipei, TaiwanDivision of Colorectal Surgery, Department of surgery, Tri-Service General Hospital, School of Medicine, National Defense Medical Center, Taipei, TaiwanBig Data Research Center, College of Medicine, Fu-Jen Catholic University, New Taipei City, TaiwanDepartment of Public Health, College of Medicine, Fu-Jen Catholic University, New Taipei City, Taiwan0Department of Psychiatry, Tri-Service General Hospital, School of Medicine, National Defense Medical Center, Taipei, Taiwan1Student Counseling Center, National Defense Medical Center, Taipei, TaiwanSchool of Public Health, National Defense Medical Center, Taipei, TaiwanDepartment of Medical Research, Tri-Service General Hospital, National Defense Medical Center, Taipei, TaiwanTaiwanese Injury Prevention and Safety Promotion Association, Taipei, Taiwan2Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, TaiwanBackground: The association between attention-deficit hypersensitivity disorder (ADHD) and the risk of developing colorectal cancer (CRC) is, as yet, to be investigated, and thus, we have conducted this nationwide, cohort study to examine the association in patients from Taiwan.Methods: In this study, 798 individuals with newly diagnosed ADHD and 2,394 (1:3) age-, gender-, and index year- matched controls without ADHD were enrolled, between 2000 and 2013, from the Longitudinal Health Insurance Database, a subset of the National Health Insurance Research Database in Taiwan. The cumulative incidence of CRC was assessed in each cohort by the Kaplan–Meier method. The multivariate Cox proportional hazards model was used to estimate the crude, and the adjusted hazards ratios (HRs) with 95% confidence intervals (CIs), was conducted to estimate the association between ADHD and CRC.Results: The Kaplan–Meier analysis revealed that the cumulative incidence of CRC was significantly higher in patients with ADHD than in those without it (log rank test, p < 0.001). After adjustments for age, gender, comorbidities, and other covariates, the ADHD group was associated with an increased risk of CRC in comparison to the non-ADHD group (adjusted HR = 3.458, 95% CI = 1.640–7.293, p < 0.001). In addition, the usage of methylphenidate was not associated with the risk of developing CRC in patients with ADHD.Conclusion: This retrospective cohort study depicts the evidence that ADHD was associated with the increased risk of CRC. Further studies are needed to confirm the association and the underlying mechanisms.https://www.frontiersin.org/articles/10.3389/fpsyt.2021.537137/fullattention-deficit hyperactivity disordercolorectal cancerretrospective cohort studyNational Health Insurance Research DatabaseLongitudinal Health Insurance Database |