HMGB1-TIM3-HO1: A New Pathway of Inflammation in Skin of SARS-CoV-2 Patients? A Retrospective Pilot Study
The SARS-CoV-2 pandemic has completely disrupted the health systems of the entire planet. From the earliest months, it became increasingly clear that in addition to affecting the upper airways and lungs, there were other organs that could be affected. Among these, the skin became a real “sentinel si...
Main Authors: | , , , , , , , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2021-08-01
|
Series: | Biomolecules |
Subjects: | |
Online Access: | https://www.mdpi.com/2218-273X/11/8/1219 |
id |
doaj-94e2d9bcdfaa48aab08b716c00dc2051 |
---|---|
record_format |
Article |
spelling |
doaj-94e2d9bcdfaa48aab08b716c00dc20512021-08-26T13:33:58ZengMDPI AGBiomolecules2218-273X2021-08-01111219121910.3390/biom11081219HMGB1-TIM3-HO1: A New Pathway of Inflammation in Skin of SARS-CoV-2 Patients? A Retrospective Pilot StudyGerardo Cazzato0Anna Colagrande1Antonietta Cimmino2Gerolamo Cicco3Vincenza Sara Scarcella4Paola Tarantino5Lucia Lospalluti6Paolo Romita7Caterina Foti8Aurora Demarco9Sara Sablone10Pragnell Maria Victoria Candance11Sebastiano Cicco12Teresa Lettini13Giuseppe Ingravallo14Leonardo Resta15Section of Pathology, Department of Emergency and Organ Transplantation (DETO), University of Bari “Aldo Moro”, 70124 Bari, ItalySection of Pathology, Department of Emergency and Organ Transplantation (DETO), University of Bari “Aldo Moro”, 70124 Bari, ItalySection of Pathology, Department of Emergency and Organ Transplantation (DETO), University of Bari “Aldo Moro”, 70124 Bari, ItalySection of Pathology, Department of Emergency and Organ Transplantation (DETO), University of Bari “Aldo Moro”, 70124 Bari, ItalySection of Pathology, Department of Emergency and Organ Transplantation (DETO), University of Bari “Aldo Moro”, 70124 Bari, ItalySection of Pathology, Department of Emergency and Organ Transplantation (DETO), University of Bari “Aldo Moro”, 70124 Bari, ItalySection of Dermatology, Department of Biomedical Sciences and Human Oncology, University of Bari “Aldo Moro”, 70124 Bari, ItalySection of Dermatology, Department of Biomedical Sciences and Human Oncology, University of Bari “Aldo Moro”, 70124 Bari, ItalySection of Dermatology, Department of Biomedical Sciences and Human Oncology, University of Bari “Aldo Moro”, 70124 Bari, ItalySection of Dermatology, Department of Biomedical Sciences and Human Oncology, University of Bari “Aldo Moro”, 70124 Bari, ItalySection of Legal Medicine, Department of Interdisciplinary Medicine, Bari Policlinico Hospital, University of Bari, 70124 Bari, ItalySection of Pathology, Department of Emergency and Organ Transplantation (DETO), University of Bari “Aldo Moro”, 70124 Bari, ItalySection of Internal Medicine “G. Baccelli”, Department of Biomedical Sciences and Human Oncology, University of Bari Medical School, 70124 Bari, ItalySection of Pathology, Department of Emergency and Organ Transplantation (DETO), University of Bari “Aldo Moro”, 70124 Bari, ItalySection of Pathology, Department of Emergency and Organ Transplantation (DETO), University of Bari “Aldo Moro”, 70124 Bari, ItalySection of Pathology, Department of Emergency and Organ Transplantation (DETO), University of Bari “Aldo Moro”, 70124 Bari, ItalyThe SARS-CoV-2 pandemic has completely disrupted the health systems of the entire planet. From the earliest months, it became increasingly clear that in addition to affecting the upper airways and lungs, there were other organs that could be affected. Among these, the skin became a real “sentinel signal” to be able to even suspect COVID-19. <i>Background</i>: this study deals with a little-explored issue for now: the study of skin immunopathology in SARS-CoV-2 positive subjects ascertained using the most reliable methods available. <i>Methods</i>: we used skin biopsy samples from SARS-CoV-2 positive and negative patients, studying morphology (Hematoxylin-Eosin), T lymphocyte population (CD4 and CD8), three markers such as HMGB-1, TIM-3 and HO-1 by immunohistochemistry. <i>Results</i>: although the presence of the CD4 and CD8 T population did not differ statistically significantly, we found greater activation and release of HMGB-1 in skin samples from SARS-CoV-2 positive patients, greater immunolabeling for TIM-3 at the level of CD4 and CD8 and a reduced expression of Heme oxygenase 1. <i>Conclusions</i>: these results support the possibility that there is immune deregulation in SARS-CoV-2 positive patients who develop skin manifestations of various kinds.https://www.mdpi.com/2218-273X/11/8/1219HMGB1TIM-3HO-1SARS-CoV-2skin |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Gerardo Cazzato Anna Colagrande Antonietta Cimmino Gerolamo Cicco Vincenza Sara Scarcella Paola Tarantino Lucia Lospalluti Paolo Romita Caterina Foti Aurora Demarco Sara Sablone Pragnell Maria Victoria Candance Sebastiano Cicco Teresa Lettini Giuseppe Ingravallo Leonardo Resta |
spellingShingle |
Gerardo Cazzato Anna Colagrande Antonietta Cimmino Gerolamo Cicco Vincenza Sara Scarcella Paola Tarantino Lucia Lospalluti Paolo Romita Caterina Foti Aurora Demarco Sara Sablone Pragnell Maria Victoria Candance Sebastiano Cicco Teresa Lettini Giuseppe Ingravallo Leonardo Resta HMGB1-TIM3-HO1: A New Pathway of Inflammation in Skin of SARS-CoV-2 Patients? A Retrospective Pilot Study Biomolecules HMGB1 TIM-3 HO-1 SARS-CoV-2 skin |
author_facet |
Gerardo Cazzato Anna Colagrande Antonietta Cimmino Gerolamo Cicco Vincenza Sara Scarcella Paola Tarantino Lucia Lospalluti Paolo Romita Caterina Foti Aurora Demarco Sara Sablone Pragnell Maria Victoria Candance Sebastiano Cicco Teresa Lettini Giuseppe Ingravallo Leonardo Resta |
author_sort |
Gerardo Cazzato |
title |
HMGB1-TIM3-HO1: A New Pathway of Inflammation in Skin of SARS-CoV-2 Patients? A Retrospective Pilot Study |
title_short |
HMGB1-TIM3-HO1: A New Pathway of Inflammation in Skin of SARS-CoV-2 Patients? A Retrospective Pilot Study |
title_full |
HMGB1-TIM3-HO1: A New Pathway of Inflammation in Skin of SARS-CoV-2 Patients? A Retrospective Pilot Study |
title_fullStr |
HMGB1-TIM3-HO1: A New Pathway of Inflammation in Skin of SARS-CoV-2 Patients? A Retrospective Pilot Study |
title_full_unstemmed |
HMGB1-TIM3-HO1: A New Pathway of Inflammation in Skin of SARS-CoV-2 Patients? A Retrospective Pilot Study |
title_sort |
hmgb1-tim3-ho1: a new pathway of inflammation in skin of sars-cov-2 patients? a retrospective pilot study |
publisher |
MDPI AG |
series |
Biomolecules |
issn |
2218-273X |
publishDate |
2021-08-01 |
description |
The SARS-CoV-2 pandemic has completely disrupted the health systems of the entire planet. From the earliest months, it became increasingly clear that in addition to affecting the upper airways and lungs, there were other organs that could be affected. Among these, the skin became a real “sentinel signal” to be able to even suspect COVID-19. <i>Background</i>: this study deals with a little-explored issue for now: the study of skin immunopathology in SARS-CoV-2 positive subjects ascertained using the most reliable methods available. <i>Methods</i>: we used skin biopsy samples from SARS-CoV-2 positive and negative patients, studying morphology (Hematoxylin-Eosin), T lymphocyte population (CD4 and CD8), three markers such as HMGB-1, TIM-3 and HO-1 by immunohistochemistry. <i>Results</i>: although the presence of the CD4 and CD8 T population did not differ statistically significantly, we found greater activation and release of HMGB-1 in skin samples from SARS-CoV-2 positive patients, greater immunolabeling for TIM-3 at the level of CD4 and CD8 and a reduced expression of Heme oxygenase 1. <i>Conclusions</i>: these results support the possibility that there is immune deregulation in SARS-CoV-2 positive patients who develop skin manifestations of various kinds. |
topic |
HMGB1 TIM-3 HO-1 SARS-CoV-2 skin |
url |
https://www.mdpi.com/2218-273X/11/8/1219 |
work_keys_str_mv |
AT gerardocazzato hmgb1tim3ho1anewpathwayofinflammationinskinofsarscov2patientsaretrospectivepilotstudy AT annacolagrande hmgb1tim3ho1anewpathwayofinflammationinskinofsarscov2patientsaretrospectivepilotstudy AT antoniettacimmino hmgb1tim3ho1anewpathwayofinflammationinskinofsarscov2patientsaretrospectivepilotstudy AT gerolamocicco hmgb1tim3ho1anewpathwayofinflammationinskinofsarscov2patientsaretrospectivepilotstudy AT vincenzasarascarcella hmgb1tim3ho1anewpathwayofinflammationinskinofsarscov2patientsaretrospectivepilotstudy AT paolatarantino hmgb1tim3ho1anewpathwayofinflammationinskinofsarscov2patientsaretrospectivepilotstudy AT lucialospalluti hmgb1tim3ho1anewpathwayofinflammationinskinofsarscov2patientsaretrospectivepilotstudy AT paoloromita hmgb1tim3ho1anewpathwayofinflammationinskinofsarscov2patientsaretrospectivepilotstudy AT caterinafoti hmgb1tim3ho1anewpathwayofinflammationinskinofsarscov2patientsaretrospectivepilotstudy AT aurorademarco hmgb1tim3ho1anewpathwayofinflammationinskinofsarscov2patientsaretrospectivepilotstudy AT sarasablone hmgb1tim3ho1anewpathwayofinflammationinskinofsarscov2patientsaretrospectivepilotstudy AT pragnellmariavictoriacandance hmgb1tim3ho1anewpathwayofinflammationinskinofsarscov2patientsaretrospectivepilotstudy AT sebastianocicco hmgb1tim3ho1anewpathwayofinflammationinskinofsarscov2patientsaretrospectivepilotstudy AT teresalettini hmgb1tim3ho1anewpathwayofinflammationinskinofsarscov2patientsaretrospectivepilotstudy AT giuseppeingravallo hmgb1tim3ho1anewpathwayofinflammationinskinofsarscov2patientsaretrospectivepilotstudy AT leonardoresta hmgb1tim3ho1anewpathwayofinflammationinskinofsarscov2patientsaretrospectivepilotstudy |
_version_ |
1721194725309939712 |