GDNF regulates the Aβ-induced endoplasmic reticulum stress response in rabbit hippocampus by inhibiting the activation of gadd 153 and the JNK and ERK kinases

GDNF regulates the Aβ-induced endoplasmic reticulum stress response in rabbit hippocampus by inhibiting the activation of gadd 153 and the JNK and ERK kinases

Glial cell line-derived neurotrophic factor (GDNF) is a potent survival agent for neurons, however, its effect on Aβ-evoked neuronal death has not been examined. We show that the injection of Aβ into New Zealand white rabbit brain activates the endoplasmic reticulum (ER) chaperones, grp 78 and grp 9...

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Bibliographic Details
Main Authors: Othman Ghribi, Mary M Herman, Patcharin Pramoonjago, Natalie K Spaulding, John Savory
Format: Article
Language:English
Published: Elsevier 2004-07-01
Series:Neurobiology of Disease
Subjects:
Aβ
GDNF
Endoplasmic reticulum
grp 78
grp 94
gadd 153
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996104000804

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http://www.sciencedirect.com/science/article/pii/S0969996104000804

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