The role of matrix metalloproteinases 2 in atherosclerosis of patients with chronic kidney disease in type 2 diabetes
Matrix metalloproteinase-2 (MMP2) has been implicated in chronic disease and cardiovascular disease. However, there is no knowledge about the correlations between serum levels of MMP-2, proteinuria and atherosclerosis in patients with diabetic nephropathy (DN). We investigated whether serum MMP-2 le...
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Wolters Kluwer Medknow Publications
2019-01-01
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Series: | Saudi Journal of Kidney Diseases and Transplantation |
Online Access: | http://www.sjkdt.org/article.asp?issn=1319-2442;year=2019;volume=30;issue=2;spage=387;epage=393;aulast=Soliman |
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doaj-94ee78dca1004dc7864346b366fc9c042020-11-25T02:56:38ZengWolters Kluwer Medknow PublicationsSaudi Journal of Kidney Diseases and Transplantation1319-24422019-01-0130238739310.4103/1319-2442.256846The role of matrix metalloproteinases 2 in atherosclerosis of patients with chronic kidney disease in type 2 diabetesAmin R SolimanKhaled M SadekKarem K ThabetDina H AhmedOsama M MohamedMatrix metalloproteinase-2 (MMP2) has been implicated in chronic disease and cardiovascular disease. However, there is no knowledge about the correlations between serum levels of MMP-2, proteinuria and atherosclerosis in patients with diabetic nephropathy (DN). We investigated whether serum MMP-2 levels were associated with proteinuria, intima-media thickness (IMT) in DN patients. Diabetic patients not on hemodialysis (n = 50) were enrolled for the study. MMP-2 levels were measured using an ELISA system. IMT was evaluated by highresolution ultrasonography. Univariate analyses revealed that MMP-2 (P = 0.013) were independent correlates of proteinuria. Further, multivariate analyses revealed that MMP-2 levels (P = 0.001) were independent correlates of IMT. MMP-2 levels were significantly (P = 0.001) higher in patients with atherosclerosis than those without it. The present study demonstrates that serum levels of MMP-2 were one of the independent correlates of proteinuria and IMT in patients with DN. Our results suggest that serum MMP-2 levels may be one of the risk factors for renal damage and atherosclerosis in DN patients.http://www.sjkdt.org/article.asp?issn=1319-2442;year=2019;volume=30;issue=2;spage=387;epage=393;aulast=Soliman |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Amin R Soliman Khaled M Sadek Karem K Thabet Dina H Ahmed Osama M Mohamed |
spellingShingle |
Amin R Soliman Khaled M Sadek Karem K Thabet Dina H Ahmed Osama M Mohamed The role of matrix metalloproteinases 2 in atherosclerosis of patients with chronic kidney disease in type 2 diabetes Saudi Journal of Kidney Diseases and Transplantation |
author_facet |
Amin R Soliman Khaled M Sadek Karem K Thabet Dina H Ahmed Osama M Mohamed |
author_sort |
Amin R Soliman |
title |
The role of matrix metalloproteinases 2 in atherosclerosis of patients with chronic kidney disease in type 2 diabetes |
title_short |
The role of matrix metalloproteinases 2 in atherosclerosis of patients with chronic kidney disease in type 2 diabetes |
title_full |
The role of matrix metalloproteinases 2 in atherosclerosis of patients with chronic kidney disease in type 2 diabetes |
title_fullStr |
The role of matrix metalloproteinases 2 in atherosclerosis of patients with chronic kidney disease in type 2 diabetes |
title_full_unstemmed |
The role of matrix metalloproteinases 2 in atherosclerosis of patients with chronic kidney disease in type 2 diabetes |
title_sort |
role of matrix metalloproteinases 2 in atherosclerosis of patients with chronic kidney disease in type 2 diabetes |
publisher |
Wolters Kluwer Medknow Publications |
series |
Saudi Journal of Kidney Diseases and Transplantation |
issn |
1319-2442 |
publishDate |
2019-01-01 |
description |
Matrix metalloproteinase-2 (MMP2) has been implicated in chronic disease and cardiovascular disease. However, there is no knowledge about the correlations between serum levels of MMP-2, proteinuria and atherosclerosis in patients with diabetic nephropathy (DN). We investigated whether serum MMP-2 levels were associated with proteinuria, intima-media thickness (IMT) in DN patients. Diabetic patients not on hemodialysis (n = 50) were enrolled for the study. MMP-2 levels were measured using an ELISA system. IMT was evaluated by highresolution ultrasonography. Univariate analyses revealed that MMP-2 (P = 0.013) were independent correlates of proteinuria. Further, multivariate analyses revealed that MMP-2 levels (P = 0.001) were independent correlates of IMT. MMP-2 levels were significantly (P = 0.001) higher in patients with atherosclerosis than those without it. The present study demonstrates that serum levels of MMP-2 were one of the independent correlates of proteinuria and IMT in patients with DN. Our results suggest that serum MMP-2 levels may be one of the risk factors for renal damage and atherosclerosis in DN patients. |
url |
http://www.sjkdt.org/article.asp?issn=1319-2442;year=2019;volume=30;issue=2;spage=387;epage=393;aulast=Soliman |
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