Developing Novel G-Quadruplex Ligands: from Interaction with Nucleic Acids to Interfering with Nucleic Acid–Protein Interaction
G-quadruplex is a special secondary structure of nucleic acids in guanine-rich sequences of genome. G-quadruplexes have been proved to be involved in the regulation of replication, DNA damage repair, and transcription and translation of oncogenes or other cancer-related genes. Therefore, targeting G...
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doaj-94f1e0285afb417bb9210cf247a71e2b2020-11-24T21:59:54ZengMDPI AGMolecules1420-30492019-01-0124339610.3390/molecules24030396molecules24030396Developing Novel G-Quadruplex Ligands: from Interaction with Nucleic Acids to Interfering with Nucleic Acid–Protein InteractionZhi-Yin Sun0Xiao-Na WangSui-Qi ChengXiao-Xuan SuTian-Miao OuSchool of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, ChinaG-quadruplex is a special secondary structure of nucleic acids in guanine-rich sequences of genome. G-quadruplexes have been proved to be involved in the regulation of replication, DNA damage repair, and transcription and translation of oncogenes or other cancer-related genes. Therefore, targeting G-quadruplexes has become a novel promising anti-tumor strategy. Different kinds of small molecules targeting the G-quadruplexes have been designed, synthesized, and identified as potential anti-tumor agents, including molecules directly bind to the G-quadruplex and molecules interfering with the binding between the G-quadruplex structures and related binding proteins. This review will explore the feasibility of G-quadruplex ligands acting as anti-tumor drugs, from basis to application. Meanwhile, since helicase is the most well-defined G-quadruplex-related protein, the most extensive research on the relationship between helicase and G-quadruplexes, and its meaning in drug design, is emphasized.https://www.mdpi.com/1420-3049/24/3/396G-quadruplexG-quadruplex ligandG-quadruplex-related proteinshelicaseanti-tumor |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Zhi-Yin Sun Xiao-Na Wang Sui-Qi Cheng Xiao-Xuan Su Tian-Miao Ou |
spellingShingle |
Zhi-Yin Sun Xiao-Na Wang Sui-Qi Cheng Xiao-Xuan Su Tian-Miao Ou Developing Novel G-Quadruplex Ligands: from Interaction with Nucleic Acids to Interfering with Nucleic Acid–Protein Interaction Molecules G-quadruplex G-quadruplex ligand G-quadruplex-related proteins helicase anti-tumor |
author_facet |
Zhi-Yin Sun Xiao-Na Wang Sui-Qi Cheng Xiao-Xuan Su Tian-Miao Ou |
author_sort |
Zhi-Yin Sun |
title |
Developing Novel G-Quadruplex Ligands: from Interaction with Nucleic Acids to Interfering with Nucleic Acid–Protein Interaction |
title_short |
Developing Novel G-Quadruplex Ligands: from Interaction with Nucleic Acids to Interfering with Nucleic Acid–Protein Interaction |
title_full |
Developing Novel G-Quadruplex Ligands: from Interaction with Nucleic Acids to Interfering with Nucleic Acid–Protein Interaction |
title_fullStr |
Developing Novel G-Quadruplex Ligands: from Interaction with Nucleic Acids to Interfering with Nucleic Acid–Protein Interaction |
title_full_unstemmed |
Developing Novel G-Quadruplex Ligands: from Interaction with Nucleic Acids to Interfering with Nucleic Acid–Protein Interaction |
title_sort |
developing novel g-quadruplex ligands: from interaction with nucleic acids to interfering with nucleic acid–protein interaction |
publisher |
MDPI AG |
series |
Molecules |
issn |
1420-3049 |
publishDate |
2019-01-01 |
description |
G-quadruplex is a special secondary structure of nucleic acids in guanine-rich sequences of genome. G-quadruplexes have been proved to be involved in the regulation of replication, DNA damage repair, and transcription and translation of oncogenes or other cancer-related genes. Therefore, targeting G-quadruplexes has become a novel promising anti-tumor strategy. Different kinds of small molecules targeting the G-quadruplexes have been designed, synthesized, and identified as potential anti-tumor agents, including molecules directly bind to the G-quadruplex and molecules interfering with the binding between the G-quadruplex structures and related binding proteins. This review will explore the feasibility of G-quadruplex ligands acting as anti-tumor drugs, from basis to application. Meanwhile, since helicase is the most well-defined G-quadruplex-related protein, the most extensive research on the relationship between helicase and G-quadruplexes, and its meaning in drug design, is emphasized. |
topic |
G-quadruplex G-quadruplex ligand G-quadruplex-related proteins helicase anti-tumor |
url |
https://www.mdpi.com/1420-3049/24/3/396 |
work_keys_str_mv |
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