Impact of Albumin and Omeprazole on Steady-State Population Pharmacokinetics of Voriconazole and Development of a Voriconazole Dosing Optimization Model in Thai Patients with Hematologic Diseases

Impact of Albumin and Omeprazole on Steady-State Population Pharmacokinetics of Voriconazole and Development of a Voriconazole Dosing Optimization Model in Thai Patients with Hematologic Diseases

This study aimed to identify factors that significantly influence the pharmacokinetics of voriconazole in Thai adults with hematologic diseases, and to determine optimal voriconazole dosing regimens. Blood samples were collected at steady state in 65 patients (237 concentrations) who were taking vor...

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Bibliographic Details
Main Authors: Buddharat Khan-asa, Baralee Punyawudho, Noppaket Singkham, Piyawat Chaivichacharn, Ekapun Karoopongse, Methee Chayakulkeeree, Preecha Montakantikul
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Antibiotics
Subjects:
population pharmacokinetics
voriconazole
albumin
omeprazole
Thai patients
Online Access:https://www.mdpi.com/2079-6382/9/9/574

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