Evasion of Antiviral Innate Immunity by Porcine Reproductive and Respiratory Syndrome Virus
Innate immunity is the front line for antiviral immune responses and bridges adaptive immunity against viral infections. However, various viruses have evolved many strategies to evade host innate immunity. A typical virus is the porcine reproductive and respiratory syndrome virus (PRRSV), one of the...
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doaj-94fe87d70906493183d19a97574c5aa02021-09-03T13:11:26ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2021-06-011210.3389/fmicb.2021.693799693799Evasion of Antiviral Innate Immunity by Porcine Reproductive and Respiratory Syndrome VirusTong-Yun Wang0Ming-Xia Sun1Hong-Liang Zhang2Gang Wang3Guoqing Zhan4Guoqing Zhan5Zhi-Jun Tian6Xue-Hui Cai7Chenhe Su8Yan-Dong Tang9State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute of Chinese Academy of Agricultural Sciences, Harbin, ChinaState Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute of Chinese Academy of Agricultural Sciences, Harbin, ChinaState Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute of Chinese Academy of Agricultural Sciences, Harbin, ChinaState Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute of Chinese Academy of Agricultural Sciences, Harbin, ChinaDepartment of Immunology, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, ChinaDepartment of Infectious Disease, Renmin Hospital, Hubei University of Medicine, Shiyan, ChinaState Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute of Chinese Academy of Agricultural Sciences, Harbin, ChinaState Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute of Chinese Academy of Agricultural Sciences, Harbin, ChinaDepartment of Immunology, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, ChinaState Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute of Chinese Academy of Agricultural Sciences, Harbin, ChinaInnate immunity is the front line for antiviral immune responses and bridges adaptive immunity against viral infections. However, various viruses have evolved many strategies to evade host innate immunity. A typical virus is the porcine reproductive and respiratory syndrome virus (PRRSV), one of the most globally devastating viruses threatening the swine industry worldwide. PRRSV engages several strategies to evade the porcine innate immune responses. This review focus on the underlying mechanisms employed by PRRSV to evade pattern recognition receptors signaling pathways, type I interferon (IFN-α/β) receptor (IFNAR)-JAK-STAT signaling pathway, and interferon-stimulated genes. Deciphering the antiviral immune evasion mechanisms by PRRSV will enhance our understanding of PRRSV’s pathogenesis and help us to develop more effective methods to control and eliminate PRRSV.https://www.frontiersin.org/articles/10.3389/fmicb.2021.693799/fullantiviral innate immunityPRRSVPRRsinterferonJAK-STATimmune evasion |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Tong-Yun Wang Ming-Xia Sun Hong-Liang Zhang Gang Wang Guoqing Zhan Guoqing Zhan Zhi-Jun Tian Xue-Hui Cai Chenhe Su Yan-Dong Tang |
spellingShingle |
Tong-Yun Wang Ming-Xia Sun Hong-Liang Zhang Gang Wang Guoqing Zhan Guoqing Zhan Zhi-Jun Tian Xue-Hui Cai Chenhe Su Yan-Dong Tang Evasion of Antiviral Innate Immunity by Porcine Reproductive and Respiratory Syndrome Virus Frontiers in Microbiology antiviral innate immunity PRRSV PRRs interferon JAK-STAT immune evasion |
author_facet |
Tong-Yun Wang Ming-Xia Sun Hong-Liang Zhang Gang Wang Guoqing Zhan Guoqing Zhan Zhi-Jun Tian Xue-Hui Cai Chenhe Su Yan-Dong Tang |
author_sort |
Tong-Yun Wang |
title |
Evasion of Antiviral Innate Immunity by Porcine Reproductive and Respiratory Syndrome Virus |
title_short |
Evasion of Antiviral Innate Immunity by Porcine Reproductive and Respiratory Syndrome Virus |
title_full |
Evasion of Antiviral Innate Immunity by Porcine Reproductive and Respiratory Syndrome Virus |
title_fullStr |
Evasion of Antiviral Innate Immunity by Porcine Reproductive and Respiratory Syndrome Virus |
title_full_unstemmed |
Evasion of Antiviral Innate Immunity by Porcine Reproductive and Respiratory Syndrome Virus |
title_sort |
evasion of antiviral innate immunity by porcine reproductive and respiratory syndrome virus |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Microbiology |
issn |
1664-302X |
publishDate |
2021-06-01 |
description |
Innate immunity is the front line for antiviral immune responses and bridges adaptive immunity against viral infections. However, various viruses have evolved many strategies to evade host innate immunity. A typical virus is the porcine reproductive and respiratory syndrome virus (PRRSV), one of the most globally devastating viruses threatening the swine industry worldwide. PRRSV engages several strategies to evade the porcine innate immune responses. This review focus on the underlying mechanisms employed by PRRSV to evade pattern recognition receptors signaling pathways, type I interferon (IFN-α/β) receptor (IFNAR)-JAK-STAT signaling pathway, and interferon-stimulated genes. Deciphering the antiviral immune evasion mechanisms by PRRSV will enhance our understanding of PRRSV’s pathogenesis and help us to develop more effective methods to control and eliminate PRRSV. |
topic |
antiviral innate immunity PRRSV PRRs interferon JAK-STAT immune evasion |
url |
https://www.frontiersin.org/articles/10.3389/fmicb.2021.693799/full |
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