Evasion of Antiviral Innate Immunity by Porcine Reproductive and Respiratory Syndrome Virus

Innate immunity is the front line for antiviral immune responses and bridges adaptive immunity against viral infections. However, various viruses have evolved many strategies to evade host innate immunity. A typical virus is the porcine reproductive and respiratory syndrome virus (PRRSV), one of the...

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Main Authors:	Tong-Yun Wang, Ming-Xia Sun, Hong-Liang Zhang, Gang Wang, Guoqing Zhan, Zhi-Jun Tian, Xue-Hui Cai, Chenhe Su, Yan-Dong Tang
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021-06-01
Series:	Frontiers in Microbiology
Subjects:	antiviral innate immunity PRRSV PRRs interferon JAK-STAT immune evasion
Online Access:	https://www.frontiersin.org/articles/10.3389/fmicb.2021.693799/full

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spelling	doaj-94fe87d70906493183d19a97574c5aa02021-09-03T13:11:26ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2021-06-011210.3389/fmicb.2021.693799693799Evasion of Antiviral Innate Immunity by Porcine Reproductive and Respiratory Syndrome VirusTong-Yun Wang0Ming-Xia Sun1Hong-Liang Zhang2Gang Wang3Guoqing Zhan4Guoqing Zhan5Zhi-Jun Tian6Xue-Hui Cai7Chenhe Su8Yan-Dong Tang9State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute of Chinese Academy of Agricultural Sciences, Harbin, ChinaState Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute of Chinese Academy of Agricultural Sciences, Harbin, ChinaState Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute of Chinese Academy of Agricultural Sciences, Harbin, ChinaState Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute of Chinese Academy of Agricultural Sciences, Harbin, ChinaDepartment of Immunology, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, ChinaDepartment of Infectious Disease, Renmin Hospital, Hubei University of Medicine, Shiyan, ChinaState Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute of Chinese Academy of Agricultural Sciences, Harbin, ChinaState Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute of Chinese Academy of Agricultural Sciences, Harbin, ChinaDepartment of Immunology, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, ChinaState Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute of Chinese Academy of Agricultural Sciences, Harbin, ChinaInnate immunity is the front line for antiviral immune responses and bridges adaptive immunity against viral infections. However, various viruses have evolved many strategies to evade host innate immunity. A typical virus is the porcine reproductive and respiratory syndrome virus (PRRSV), one of the most globally devastating viruses threatening the swine industry worldwide. PRRSV engages several strategies to evade the porcine innate immune responses. This review focus on the underlying mechanisms employed by PRRSV to evade pattern recognition receptors signaling pathways, type I interferon (IFN-α/β) receptor (IFNAR)-JAK-STAT signaling pathway, and interferon-stimulated genes. Deciphering the antiviral immune evasion mechanisms by PRRSV will enhance our understanding of PRRSV’s pathogenesis and help us to develop more effective methods to control and eliminate PRRSV.https://www.frontiersin.org/articles/10.3389/fmicb.2021.693799/fullantiviral innate immunityPRRSVPRRsinterferonJAK-STATimmune evasion
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Tong-Yun Wang Ming-Xia Sun Hong-Liang Zhang Gang Wang Guoqing Zhan Guoqing Zhan Zhi-Jun Tian Xue-Hui Cai Chenhe Su Yan-Dong Tang
spellingShingle	Tong-Yun Wang Ming-Xia Sun Hong-Liang Zhang Gang Wang Guoqing Zhan Guoqing Zhan Zhi-Jun Tian Xue-Hui Cai Chenhe Su Yan-Dong Tang Evasion of Antiviral Innate Immunity by Porcine Reproductive and Respiratory Syndrome Virus Frontiers in Microbiology antiviral innate immunity PRRSV PRRs interferon JAK-STAT immune evasion
author_facet	Tong-Yun Wang Ming-Xia Sun Hong-Liang Zhang Gang Wang Guoqing Zhan Guoqing Zhan Zhi-Jun Tian Xue-Hui Cai Chenhe Su Yan-Dong Tang
author_sort	Tong-Yun Wang
title	Evasion of Antiviral Innate Immunity by Porcine Reproductive and Respiratory Syndrome Virus
title_short	Evasion of Antiviral Innate Immunity by Porcine Reproductive and Respiratory Syndrome Virus
title_full	Evasion of Antiviral Innate Immunity by Porcine Reproductive and Respiratory Syndrome Virus
title_fullStr	Evasion of Antiviral Innate Immunity by Porcine Reproductive and Respiratory Syndrome Virus
title_full_unstemmed	Evasion of Antiviral Innate Immunity by Porcine Reproductive and Respiratory Syndrome Virus
title_sort	evasion of antiviral innate immunity by porcine reproductive and respiratory syndrome virus
publisher	Frontiers Media S.A.
series	Frontiers in Microbiology
issn	1664-302X
publishDate	2021-06-01
description	Innate immunity is the front line for antiviral immune responses and bridges adaptive immunity against viral infections. However, various viruses have evolved many strategies to evade host innate immunity. A typical virus is the porcine reproductive and respiratory syndrome virus (PRRSV), one of the most globally devastating viruses threatening the swine industry worldwide. PRRSV engages several strategies to evade the porcine innate immune responses. This review focus on the underlying mechanisms employed by PRRSV to evade pattern recognition receptors signaling pathways, type I interferon (IFN-α/β) receptor (IFNAR)-JAK-STAT signaling pathway, and interferon-stimulated genes. Deciphering the antiviral immune evasion mechanisms by PRRSV will enhance our understanding of PRRSV’s pathogenesis and help us to develop more effective methods to control and eliminate PRRSV.
topic	antiviral innate immunity PRRSV PRRs interferon JAK-STAT immune evasion
url	https://www.frontiersin.org/articles/10.3389/fmicb.2021.693799/full
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Evasion of Antiviral Innate Immunity by Porcine Reproductive and Respiratory Syndrome Virus

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