Outcome of Pregnancy in the Era of Pegylated Interferon Alpha 2a in Females with Essential Thrombocythemia: An Experience from Qatar

Myeloproliferative neoplasms are a diversified group of diseases of the hematopoietic stem cell, such as essential thrombocythemia (ET) and polycythemia vera. They are mainly caused by mutations in the following genes: JAK2, CALR, and MPL. All carry an increased risk to transform into acute leukemia...

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Main Authors:	Mohammad Abu-Tineh, Nancy Kassem, Mohammad Abdul-Jaber Abdulla, Omar Mohammad Ismail, Rola Ghasoub, Mahmood B. Aldapt, Mohamed A. Yassin
Format:	Article
Language:	English
Published:	Karger Publishers 2020-03-01
Series:	Case Reports in Oncology
Subjects:	essential thrombocythemia myeloproliferative neoplasms interferon peg-ifn alpha-2a pregnancy
Online Access:	https://www.karger.com/Article/FullText/506447

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spelling	doaj-950a1ceaa12f463785ce0d5337abf4a42020-11-25T02:02:51ZengKarger PublishersCase Reports in Oncology1662-65752020-03-0113133634010.1159/000506447506447Outcome of Pregnancy in the Era of Pegylated Interferon Alpha 2a in Females with Essential Thrombocythemia: An Experience from QatarMohammad Abu-TinehNancy KassemMohammad Abdul-Jaber AbdullaOmar Mohammad IsmailRola GhasoubMahmood B. AldaptMohamed A. YassinMyeloproliferative neoplasms are a diversified group of diseases of the hematopoietic stem cell, such as essential thrombocythemia (ET) and polycythemia vera. They are mainly caused by mutations in the following genes: JAK2, CALR, and MPL. All carry an increased risk to transform into acute leukemia or chronic myelogenous leukemia along with thrombosis and hemorrhagic complications. Treatment of such disorders during pregnancy is a challenging footstep, given the high risk of complications for both the mother and the fetus. Here, we report about two pregnant females with ET that has been treated with pegylated interferon alpha with safe and effective outcome.https://www.karger.com/Article/FullText/506447essential thrombocythemiamyeloproliferative neoplasmsinterferonpeg-ifn alpha-2apregnancy
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Mohammad Abu-Tineh Nancy Kassem Mohammad Abdul-Jaber Abdulla Omar Mohammad Ismail Rola Ghasoub Mahmood B. Aldapt Mohamed A. Yassin
spellingShingle	Mohammad Abu-Tineh Nancy Kassem Mohammad Abdul-Jaber Abdulla Omar Mohammad Ismail Rola Ghasoub Mahmood B. Aldapt Mohamed A. Yassin Outcome of Pregnancy in the Era of Pegylated Interferon Alpha 2a in Females with Essential Thrombocythemia: An Experience from Qatar Case Reports in Oncology essential thrombocythemia myeloproliferative neoplasms interferon peg-ifn alpha-2a pregnancy
author_facet	Mohammad Abu-Tineh Nancy Kassem Mohammad Abdul-Jaber Abdulla Omar Mohammad Ismail Rola Ghasoub Mahmood B. Aldapt Mohamed A. Yassin
author_sort	Mohammad Abu-Tineh
title	Outcome of Pregnancy in the Era of Pegylated Interferon Alpha 2a in Females with Essential Thrombocythemia: An Experience from Qatar
title_short	Outcome of Pregnancy in the Era of Pegylated Interferon Alpha 2a in Females with Essential Thrombocythemia: An Experience from Qatar
title_full	Outcome of Pregnancy in the Era of Pegylated Interferon Alpha 2a in Females with Essential Thrombocythemia: An Experience from Qatar
title_fullStr	Outcome of Pregnancy in the Era of Pegylated Interferon Alpha 2a in Females with Essential Thrombocythemia: An Experience from Qatar
title_full_unstemmed	Outcome of Pregnancy in the Era of Pegylated Interferon Alpha 2a in Females with Essential Thrombocythemia: An Experience from Qatar
title_sort	outcome of pregnancy in the era of pegylated interferon alpha 2a in females with essential thrombocythemia: an experience from qatar
publisher	Karger Publishers
series	Case Reports in Oncology
issn	1662-6575
publishDate	2020-03-01
description	Myeloproliferative neoplasms are a diversified group of diseases of the hematopoietic stem cell, such as essential thrombocythemia (ET) and polycythemia vera. They are mainly caused by mutations in the following genes: JAK2, CALR, and MPL. All carry an increased risk to transform into acute leukemia or chronic myelogenous leukemia along with thrombosis and hemorrhagic complications. Treatment of such disorders during pregnancy is a challenging footstep, given the high risk of complications for both the mother and the fetus. Here, we report about two pregnant females with ET that has been treated with pegylated interferon alpha with safe and effective outcome.
topic	essential thrombocythemia myeloproliferative neoplasms interferon peg-ifn alpha-2a pregnancy
url	https://www.karger.com/Article/FullText/506447
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Outcome of Pregnancy in the Era of Pegylated Interferon Alpha 2a in Females with Essential Thrombocythemia: An Experience from Qatar

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