Early Life Adversity and Adult Social Behavior: Focus on Arginine Vasopressin and Oxytocin as Potential Mediators
Exposure to stress during the early postnatal period (i.e., early life stress, ES) can impact brain physiology and modify individual variability in adult social behavior. Arginine vasopressin (AVP) and oxytocin (OXT) are two centrally released neuropeptides that are involved in shaping essential soc...
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doaj-950cd7fd2a554276a0be212048ddf42d2020-11-24T21:27:38ZengFrontiers Media S.A.Frontiers in Behavioral Neuroscience1662-51532019-07-011310.3389/fnbeh.2019.00143460542Early Life Adversity and Adult Social Behavior: Focus on Arginine Vasopressin and Oxytocin as Potential MediatorsNine F. Kompier0Nine F. Kompier1Christian Keysers2Christian Keysers3Valeria Gazzola4Valeria Gazzola5Paul J. Lucassen6Harmen J. Krugers7Brain Plasticity Group, Swammerdam Institute for Life Sciences, Center for Neuroscience, University of Amsterdam, Amsterdam, NetherlandsSocial Brain Lab, Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences, Amsterdam, NetherlandsSocial Brain Lab, Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences, Amsterdam, NetherlandsDepartment of Psychology, University of Amsterdam, Amsterdam, NetherlandsSocial Brain Lab, Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences, Amsterdam, NetherlandsDepartment of Psychology, University of Amsterdam, Amsterdam, NetherlandsBrain Plasticity Group, Swammerdam Institute for Life Sciences, Center for Neuroscience, University of Amsterdam, Amsterdam, NetherlandsBrain Plasticity Group, Swammerdam Institute for Life Sciences, Center for Neuroscience, University of Amsterdam, Amsterdam, NetherlandsExposure to stress during the early postnatal period (i.e., early life stress, ES) can impact brain physiology and modify individual variability in adult social behavior. Arginine vasopressin (AVP) and oxytocin (OXT) are two centrally released neuropeptides that are involved in shaping essential social behaviors, like aggression, social recognition, and social motivation. AVP and OXT modulate activity in brain regions important for the establishment of social behavior, and may be particularly sensitive to ES. In this review, we discuss whether ES alters the characteristics of the AVP- and OXT- systems in rodents, and whether these changes are associated with later alterations in aggression, social recognition, and social motivation. We have integrated causal studies indicating that (1) ES affects AVP/OXT, and (2) that changing AVP/OXT in affected regions alters social behavior. Although there is encouraging evidence that ES causes AVP- and OXT-system changes, and that these may mediate social behavior, a comprehensive understanding of the exact nature of AVP- and OXT changes and whether they are causal in establishing these behavioral disturbances needs further investigation. As there are indications that ES alters AVP- and OXT characteristics in humans as well, and that these may interact with adult predisposition to psychopathology with social dysfunction, future rodent studies may lay ground for a better understanding of such changes in humans. Ultimately, this may assist in developing therapeutic strategies to target ES effects on social behavior.https://www.frontiersin.org/article/10.3389/fnbeh.2019.00143/fullearly life stressoxytocinvasopressinsocial behavioraggressionsocial recognition |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Nine F. Kompier Nine F. Kompier Christian Keysers Christian Keysers Valeria Gazzola Valeria Gazzola Paul J. Lucassen Harmen J. Krugers |
spellingShingle |
Nine F. Kompier Nine F. Kompier Christian Keysers Christian Keysers Valeria Gazzola Valeria Gazzola Paul J. Lucassen Harmen J. Krugers Early Life Adversity and Adult Social Behavior: Focus on Arginine Vasopressin and Oxytocin as Potential Mediators Frontiers in Behavioral Neuroscience early life stress oxytocin vasopressin social behavior aggression social recognition |
author_facet |
Nine F. Kompier Nine F. Kompier Christian Keysers Christian Keysers Valeria Gazzola Valeria Gazzola Paul J. Lucassen Harmen J. Krugers |
author_sort |
Nine F. Kompier |
title |
Early Life Adversity and Adult Social Behavior: Focus on Arginine Vasopressin and Oxytocin as Potential Mediators |
title_short |
Early Life Adversity and Adult Social Behavior: Focus on Arginine Vasopressin and Oxytocin as Potential Mediators |
title_full |
Early Life Adversity and Adult Social Behavior: Focus on Arginine Vasopressin and Oxytocin as Potential Mediators |
title_fullStr |
Early Life Adversity and Adult Social Behavior: Focus on Arginine Vasopressin and Oxytocin as Potential Mediators |
title_full_unstemmed |
Early Life Adversity and Adult Social Behavior: Focus on Arginine Vasopressin and Oxytocin as Potential Mediators |
title_sort |
early life adversity and adult social behavior: focus on arginine vasopressin and oxytocin as potential mediators |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Behavioral Neuroscience |
issn |
1662-5153 |
publishDate |
2019-07-01 |
description |
Exposure to stress during the early postnatal period (i.e., early life stress, ES) can impact brain physiology and modify individual variability in adult social behavior. Arginine vasopressin (AVP) and oxytocin (OXT) are two centrally released neuropeptides that are involved in shaping essential social behaviors, like aggression, social recognition, and social motivation. AVP and OXT modulate activity in brain regions important for the establishment of social behavior, and may be particularly sensitive to ES. In this review, we discuss whether ES alters the characteristics of the AVP- and OXT- systems in rodents, and whether these changes are associated with later alterations in aggression, social recognition, and social motivation. We have integrated causal studies indicating that (1) ES affects AVP/OXT, and (2) that changing AVP/OXT in affected regions alters social behavior. Although there is encouraging evidence that ES causes AVP- and OXT-system changes, and that these may mediate social behavior, a comprehensive understanding of the exact nature of AVP- and OXT changes and whether they are causal in establishing these behavioral disturbances needs further investigation. As there are indications that ES alters AVP- and OXT characteristics in humans as well, and that these may interact with adult predisposition to psychopathology with social dysfunction, future rodent studies may lay ground for a better understanding of such changes in humans. Ultimately, this may assist in developing therapeutic strategies to target ES effects on social behavior. |
topic |
early life stress oxytocin vasopressin social behavior aggression social recognition |
url |
https://www.frontiersin.org/article/10.3389/fnbeh.2019.00143/full |
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