Human ribonuclease 1 serves as a secretory ligand of ephrin A4 receptor and induces breast tumor initiation
Human ribonuclease 1 (hRNase 1) regulates innate immunity, hemostasis and RNA clearance. Here, the authors report an alternative function of hRNase 1 as a secretory ligand of Eph receptor EphA4 to enhance breast cancer stemness and promote breast tumour initiation.
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2021-05-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-23075-2 |
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doaj-951d591c8f644e74b61e110feda5e0962021-05-16T11:09:40ZengNature Publishing GroupNature Communications2041-17232021-05-0112111810.1038/s41467-021-23075-2Human ribonuclease 1 serves as a secretory ligand of ephrin A4 receptor and induces breast tumor initiationHeng-Huan Lee0Ying-Nai Wang1Wen-Hao Yang2Weiya Xia3Yongkun Wei4Li-Chuan Chan5Yu-Han Wang6Zhou Jiang7Shouping Xu8Jun Yao9Yufan Qiu10Yi-Hsin Hsu11Wei-Lun Hwang12Meisi Yan13Jong-Ho Cha14Jennifer L. Hsu15Jia Shen16Yuanqing Ye17Xifeng Wu18Ming-Feng Hou19Lin-Ming Tseng20Shao-Chun Wang21Mei-Ren Pan22Chin-Hua Yang23Yuan-Liang Wang24Hirohito Yamaguchi25Da Pang26Gabriel N. Hortobagyi27Dihua Yu28Mien-Chie Hung29Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer CenterDepartment of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer CenterDepartment of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer CenterDepartment of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer CenterDepartment of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer CenterDepartment of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer CenterDepartment of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer CenterDepartment of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer CenterDepartment of Breast Surgery, Harbin Medical University Cancer HospitalDepartment of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer CenterDepartment of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer CenterDepartment of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer CenterDepartment of Biotechnology and Laboratory Science in Medicine, National Yang Ming Chiao Tung UniversityDepartment of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer CenterDepartment of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer CenterDepartment of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer CenterDepartment of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer CenterDepartment of Epidemiology, The University of Texas MD Anderson Cancer CenterDepartment of Epidemiology, The University of Texas MD Anderson Cancer CenterDivision of Breast Surgery, Department of Surgery, Kaohsiung Medical University HospitalComprehensive Breast Health Center and Division of General Surgery, Department of Surgery, Taipei Veterans General HospitalGraduate Institute of Biomedical Sciences, Research Center for Cancer Biology, and Center for Molecular Medicine, China Medical UniversityGraduate Institute of Clinical Medicine, Kaohsiung Medical UniversityComprehensive Breast Health Center and Division of General Surgery, Department of Surgery, Taipei Veterans General HospitalGraduate Institute of Biomedical Sciences, Research Center for Cancer Biology, and Center for Molecular Medicine, China Medical UniversityDepartment of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer CenterDepartment of Breast Surgery, Harbin Medical University Cancer HospitalDepartment of Breast Medical Oncology, The University of Texas MD Anderson Cancer CenterDepartment of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer CenterDepartment of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer CenterHuman ribonuclease 1 (hRNase 1) regulates innate immunity, hemostasis and RNA clearance. Here, the authors report an alternative function of hRNase 1 as a secretory ligand of Eph receptor EphA4 to enhance breast cancer stemness and promote breast tumour initiation.https://doi.org/10.1038/s41467-021-23075-2 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Heng-Huan Lee Ying-Nai Wang Wen-Hao Yang Weiya Xia Yongkun Wei Li-Chuan Chan Yu-Han Wang Zhou Jiang Shouping Xu Jun Yao Yufan Qiu Yi-Hsin Hsu Wei-Lun Hwang Meisi Yan Jong-Ho Cha Jennifer L. Hsu Jia Shen Yuanqing Ye Xifeng Wu Ming-Feng Hou Lin-Ming Tseng Shao-Chun Wang Mei-Ren Pan Chin-Hua Yang Yuan-Liang Wang Hirohito Yamaguchi Da Pang Gabriel N. Hortobagyi Dihua Yu Mien-Chie Hung |
| spellingShingle |
Heng-Huan Lee Ying-Nai Wang Wen-Hao Yang Weiya Xia Yongkun Wei Li-Chuan Chan Yu-Han Wang Zhou Jiang Shouping Xu Jun Yao Yufan Qiu Yi-Hsin Hsu Wei-Lun Hwang Meisi Yan Jong-Ho Cha Jennifer L. Hsu Jia Shen Yuanqing Ye Xifeng Wu Ming-Feng Hou Lin-Ming Tseng Shao-Chun Wang Mei-Ren Pan Chin-Hua Yang Yuan-Liang Wang Hirohito Yamaguchi Da Pang Gabriel N. Hortobagyi Dihua Yu Mien-Chie Hung Human ribonuclease 1 serves as a secretory ligand of ephrin A4 receptor and induces breast tumor initiation Nature Communications |
| author_facet |
Heng-Huan Lee Ying-Nai Wang Wen-Hao Yang Weiya Xia Yongkun Wei Li-Chuan Chan Yu-Han Wang Zhou Jiang Shouping Xu Jun Yao Yufan Qiu Yi-Hsin Hsu Wei-Lun Hwang Meisi Yan Jong-Ho Cha Jennifer L. Hsu Jia Shen Yuanqing Ye Xifeng Wu Ming-Feng Hou Lin-Ming Tseng Shao-Chun Wang Mei-Ren Pan Chin-Hua Yang Yuan-Liang Wang Hirohito Yamaguchi Da Pang Gabriel N. Hortobagyi Dihua Yu Mien-Chie Hung |
| author_sort |
Heng-Huan Lee |
| title |
Human ribonuclease 1 serves as a secretory ligand of ephrin A4 receptor and induces breast tumor initiation |
| title_short |
Human ribonuclease 1 serves as a secretory ligand of ephrin A4 receptor and induces breast tumor initiation |
| title_full |
Human ribonuclease 1 serves as a secretory ligand of ephrin A4 receptor and induces breast tumor initiation |
| title_fullStr |
Human ribonuclease 1 serves as a secretory ligand of ephrin A4 receptor and induces breast tumor initiation |
| title_full_unstemmed |
Human ribonuclease 1 serves as a secretory ligand of ephrin A4 receptor and induces breast tumor initiation |
| title_sort |
human ribonuclease 1 serves as a secretory ligand of ephrin a4 receptor and induces breast tumor initiation |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2021-05-01 |
| description |
Human ribonuclease 1 (hRNase 1) regulates innate immunity, hemostasis and RNA clearance. Here, the authors report an alternative function of hRNase 1 as a secretory ligand of Eph receptor EphA4 to enhance breast cancer stemness and promote breast tumour initiation. |
| url |
https://doi.org/10.1038/s41467-021-23075-2 |
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