Comparative characteristics of original and non-original sevoflurane in urological operations in children: a prospective study results

• Main Authors: D. V. Prometnoy, A. D. Mayorov, М. V. Bykov, V. O. Fedyushkina, P. Е. Anchutin, А. D. Pamfiynik, S. A. Razumov
• Format: Article
• Language: Russian
• Published: ABV-press 2020-11-01
• Series: Andrologiâ i Genitalʹnaâ Hirurgiâ
• Subjects: sevoflurane; original drug; nonoriginal drug; generic drug; anesthesia; children
• Online Access: https://agx.abvpress.ru/jour/article/view/435

The study objective is to evaluate the effectiveness and safety of the original and non-original sevoflurane during urological operations in children.Materials and methods. Patients of urological profile 3—6 years old without comorbid pathology underwent surgery lasting no more than 40 min under inhalation anesthesia: in group 1 — original sevoflurane (n = 11), group 2 — non-original sevoflurane (n = 11). The depth of anesthesia was evaluated using bispectral index monitoring.Results. In the group of non-original sevoflurane, the excitation syndrome before the beginning of anesthesia and in its introductory period was noted in 54.5 and 72.7 % respectively, the reaction to the introduction of a laryngeal mask — in 36.4 % of patients in the absence of these reactions in the group of the original drug. There was a higher depth of anesthesia in non-original drug with the achievement of statistically significant differences in the indicator at 15 and 20 min: 44 (42; 46) vs 50 (49; 54; p = 0.0001) and 42 (40; 46) vs 50 (47; 56; p = 0.003) respectively, as well unstable level of depth of anesthesia of the group of non-original sevoflurane compared to the original during the period of maintaining anesthesia.Conclusion. Despite the same formula of the original and non-original sevoflurane, the non-original drug was characterized by a greater frequency of excitation syndrome and reaction to the introduction of a laryngeal mask and unstable depth of anesthesia.