Clinical Application of Serum Inflammatory Factors Combined With Dynamic Detection in the Diagnosis and Treatment of Ne-onatal Sepsis

• Main Authors: Dahong SUN, Qing WANG, Xiaoyan ZHANG, Xiuzhen ZHAO ZHAO, Haiyan ZHANG, Aimei LIU
• Format: Article
• Language: English
• Published: Tehran University of Medical Sciences 2021-02-01
• Series: Iranian Journal of Public Health
• Subjects: Sepsis; Newborn; C-reactive protein; Procalcitonin; Interleukin-6; Combined detection
• Online Access: https://ijph.tums.ac.ir/index.php/ijph/article/view/21864

Background: To investigate the clinical application value of the combination of the inflammatory factors and dynamic detection in the diagnosis and treatment of neonatal sepsis by detecting serum inflammatory factor C-reactive protein (CRP), procalcitonin (PCT), and interleukin-6 (IL-6) levels before and after treatment of neonatal infection.  Methods: A total of 138 neonates with different degrees of infection were randomly enrolled, including 88 cases in the sepsis group and 50 cases in the virus infection group. Another 50 non-infected newborns in the same period were enrolled as the normal control group. Venous blood of all subjects for CRP, PCT, IL-6 detection, and send bacterial blood culture for sepsis and virus infection groups were collected at the same time. In the recovery period, venous blood of children in sepsis group was collected again to review CRP, PCT, IL-6, and differences in each test index of each group were compared. Results: The serum CRP, PCT, IL-6 levels in the sepsis group were significantly higher than those in the virus infection group (all P <0.05); serum CRP, PCT, IL-6 levels in the sepsis group were significantly lower than before treatment (P <0.05); the sensitivity and accuracy of the combined detection of indicators for the diagnosis of neonatal sepsis were significantly improved. Conclusion: The inflammatory factors CRP, PCT, and IL-6 are closely related to the occurrence and development of neonatal sepsis. Combined detection can effectively improve the diagnostic accordance rate, which is beneficial to the early diagnosis and early clinical intervention of neonatal sepsis.