Comparing Cerebral White Matter Lesion Burdens between Parkinson’s Disease with and without Dementia
Cerebral white matter lesions (CWMLs) have been suggested to be associated with an increased risk of dementia, disability, and death. CWMLs are more common in individuals with Alzheimer’s disease (AD) than in normal elderly individuals of comparable age. Only a few studies have been done to determin...
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Korean Movement Disorders Society
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doaj-95269331343f4236bab41634162170372020-11-24T23:11:58ZengKorean Movement Disorders SocietyJournal of Movement Disorders2005-940X2093-49392010-05-013161010.14802/jmd.1000254Comparing Cerebral White Matter Lesion Burdens between Parkinson’s Disease with and without DementiaSun-Ah ChoiVirgilio Gerald H. EvidenteJohn N CavinessCerebral white matter lesions (CWMLs) have been suggested to be associated with an increased risk of dementia, disability, and death. CWMLs are more common in individuals with Alzheimer’s disease (AD) than in normal elderly individuals of comparable age. Only a few studies have been done to determine whether CWMLs may influence cognitive decline in Parkinson’s disease (PD). Fully developed PD with concurrent AD was reported to likely cause impaired cognition in spite of accumulating evidence suggesting that PD with dementia (PDD) is more closely associated with Lewy body (LB) pathology. Currently, contradictory data on the neuropathology of dementia in PD require further prospective clinicopathological studies in larger cohorts to elucidate the impact of AD and α-synuclein (SCNA) pathologies on the cognitive status in these disorders. Previous reports did not suggest CWMLs to be associated with an increased risk of PDD. After adjusting for age at death, age at onset of PD, and duration of PD, our recent study investigating CWMLs in PDD via autopsy has shown a positive correlation between the burden of CWMLs and PDD. The frequent co-existence of both LB and AD lesions suggests that both pathologies independently or synergistically contribute to both movement disorders and cognitive impairment. The individual and cumulative burden of CWMLs, LB lesions, and AD lesions may synergistically contribute to cognitive decline in LB disorders such as PDD.http://e-jmd.org/upload/jmd-3-1-6-2.pdfParkinson’s diseaseWhite matter lesionsDementia |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Sun-Ah Choi Virgilio Gerald H. Evidente John N Caviness |
spellingShingle |
Sun-Ah Choi Virgilio Gerald H. Evidente John N Caviness Comparing Cerebral White Matter Lesion Burdens between Parkinson’s Disease with and without Dementia Journal of Movement Disorders Parkinson’s disease White matter lesions Dementia |
author_facet |
Sun-Ah Choi Virgilio Gerald H. Evidente John N Caviness |
author_sort |
Sun-Ah Choi |
title |
Comparing Cerebral White Matter Lesion Burdens between Parkinson’s Disease with and without Dementia |
title_short |
Comparing Cerebral White Matter Lesion Burdens between Parkinson’s Disease with and without Dementia |
title_full |
Comparing Cerebral White Matter Lesion Burdens between Parkinson’s Disease with and without Dementia |
title_fullStr |
Comparing Cerebral White Matter Lesion Burdens between Parkinson’s Disease with and without Dementia |
title_full_unstemmed |
Comparing Cerebral White Matter Lesion Burdens between Parkinson’s Disease with and without Dementia |
title_sort |
comparing cerebral white matter lesion burdens between parkinson’s disease with and without dementia |
publisher |
Korean Movement Disorders Society |
series |
Journal of Movement Disorders |
issn |
2005-940X 2093-4939 |
publishDate |
2010-05-01 |
description |
Cerebral white matter lesions (CWMLs) have been suggested to be associated with an increased risk of dementia, disability, and death. CWMLs are more common in individuals with Alzheimer’s disease (AD) than in normal elderly individuals of comparable age. Only a few studies have been done to determine whether CWMLs may influence cognitive decline in Parkinson’s disease (PD). Fully developed PD with concurrent AD was reported to likely cause impaired cognition in spite of accumulating evidence suggesting that PD with dementia (PDD) is more closely associated with Lewy body (LB) pathology. Currently, contradictory data on the neuropathology of dementia in PD require further prospective clinicopathological studies in larger cohorts to elucidate the impact of AD and α-synuclein (SCNA) pathologies on the cognitive status in these disorders. Previous reports did not suggest CWMLs to be associated with an increased risk of PDD. After adjusting for age at death, age at onset of PD, and duration of PD, our recent study investigating CWMLs in PDD via autopsy has shown a positive correlation between the burden of CWMLs and PDD. The frequent co-existence of both LB and AD lesions suggests that both pathologies independently or synergistically contribute to both movement disorders and cognitive impairment. The individual and cumulative burden of CWMLs, LB lesions, and AD lesions may synergistically contribute to cognitive decline in LB disorders such as PDD. |
topic |
Parkinson’s disease White matter lesions Dementia |
url |
http://e-jmd.org/upload/jmd-3-1-6-2.pdf |
work_keys_str_mv |
AT sunahchoi comparingcerebralwhitematterlesionburdensbetweenparkinsonsdiseasewithandwithoutdementia AT virgiliogeraldhevidente comparingcerebralwhitematterlesionburdensbetweenparkinsonsdiseasewithandwithoutdementia AT johnncaviness comparingcerebralwhitematterlesionburdensbetweenparkinsonsdiseasewithandwithoutdementia |
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