Vitamin D3 concentration correlates with the severity of multiple sclerosis

Background: To investigate the possible association between serum 25(OH) vitamin D 3 concentration and the severity of disease in Iranian patients with multiple sclerosis (MS) and to compare this concentration with a matched control group. Methods: This was an analytical cross-sectional study perfo...

Full description

Bibliographic Details
Main Authors: Saeed Shahbeigi, Hossein Pakdaman, Seyed-Mohammad Fereshtehnejad, Elham Nikravesh, Nazanin Mirabi, Ghazal Jalilzadeh
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2013-01-01
Series:International Journal of Preventive Medicine
Subjects:
Online Access:http://www.ijpvmjournal.net/article.asp?issn=2008-7802;year=2013;volume=4;issue=5;spage=585;epage=591;aulast=Shahbeigi
id doaj-952733c1f0b243e791ad227ccf56744e
record_format Article
spelling doaj-952733c1f0b243e791ad227ccf56744e2020-11-24T23:25:30ZengWolters Kluwer Medknow PublicationsInternational Journal of Preventive Medicine2008-78022008-82132013-01-0145585591Vitamin D3 concentration correlates with the severity of multiple sclerosisSaeed ShahbeigiHossein PakdamanSeyed-Mohammad FereshtehnejadElham NikraveshNazanin MirabiGhazal JalilzadehBackground: To investigate the possible association between serum 25(OH) vitamin D 3 concentration and the severity of disease in Iranian patients with multiple sclerosis (MS) and to compare this concentration with a matched control group. Methods: This was an analytical cross-sectional study performed at Jondishapour Neurology Clinic in Tehran, Iran. Patients with relapsing-remitting MS were categorized by disease severity: mild [0≤ Expanded Disability Status Scale (EDSS) ≤3], moderate (3.5≤EDSS≤5.5), and severe (6≤EDSS). Serum concentrations of 25(OH) vitamin D 3 , calcium, phosphorus, magnesium, and parathyroid hormone were measured in 98 MS patients and 17 healthy age- and sex-matched controls. Fisher′s exact, Kruskal-Wallis, Mann-Whitney U test, and independent t and Spearman rank correlation tests were used. Results: Serum 25(OH) vitamin D 3 concentration was significantly lower in patients with MS, especially in the severe MS subgroup, compared with healthy controls (P=0.047). There was a statistically significant inverse correlation between 25(OH) vitamin D 3 concentration and EDSS score (P=0.049, R=-0.168 by Spearman rank correlation test), which was observed in women only (P=0.044, R=-0.199). Conclusions: Our findings not only further disclose the lower level of vitamin D in MS patients in comparison with healthy controls, but also support the association between vitamin D and disease severity in MS.http://www.ijpvmjournal.net/article.asp?issn=2008-7802;year=2013;volume=4;issue=5;spage=585;epage=591;aulast=Shahbeigi25(OH) vitamin D 3disease severitymultiple sclerosis
collection DOAJ
language English
format Article
sources DOAJ
author Saeed Shahbeigi
Hossein Pakdaman
Seyed-Mohammad Fereshtehnejad
Elham Nikravesh
Nazanin Mirabi
Ghazal Jalilzadeh
spellingShingle Saeed Shahbeigi
Hossein Pakdaman
Seyed-Mohammad Fereshtehnejad
Elham Nikravesh
Nazanin Mirabi
Ghazal Jalilzadeh
Vitamin D3 concentration correlates with the severity of multiple sclerosis
International Journal of Preventive Medicine
25(OH) vitamin D 3
disease severity
multiple sclerosis
author_facet Saeed Shahbeigi
Hossein Pakdaman
Seyed-Mohammad Fereshtehnejad
Elham Nikravesh
Nazanin Mirabi
Ghazal Jalilzadeh
author_sort Saeed Shahbeigi
title Vitamin D3 concentration correlates with the severity of multiple sclerosis
title_short Vitamin D3 concentration correlates with the severity of multiple sclerosis
title_full Vitamin D3 concentration correlates with the severity of multiple sclerosis
title_fullStr Vitamin D3 concentration correlates with the severity of multiple sclerosis
title_full_unstemmed Vitamin D3 concentration correlates with the severity of multiple sclerosis
title_sort vitamin d3 concentration correlates with the severity of multiple sclerosis
publisher Wolters Kluwer Medknow Publications
series International Journal of Preventive Medicine
issn 2008-7802
2008-8213
publishDate 2013-01-01
description Background: To investigate the possible association between serum 25(OH) vitamin D 3 concentration and the severity of disease in Iranian patients with multiple sclerosis (MS) and to compare this concentration with a matched control group. Methods: This was an analytical cross-sectional study performed at Jondishapour Neurology Clinic in Tehran, Iran. Patients with relapsing-remitting MS were categorized by disease severity: mild [0≤ Expanded Disability Status Scale (EDSS) ≤3], moderate (3.5≤EDSS≤5.5), and severe (6≤EDSS). Serum concentrations of 25(OH) vitamin D 3 , calcium, phosphorus, magnesium, and parathyroid hormone were measured in 98 MS patients and 17 healthy age- and sex-matched controls. Fisher′s exact, Kruskal-Wallis, Mann-Whitney U test, and independent t and Spearman rank correlation tests were used. Results: Serum 25(OH) vitamin D 3 concentration was significantly lower in patients with MS, especially in the severe MS subgroup, compared with healthy controls (P=0.047). There was a statistically significant inverse correlation between 25(OH) vitamin D 3 concentration and EDSS score (P=0.049, R=-0.168 by Spearman rank correlation test), which was observed in women only (P=0.044, R=-0.199). Conclusions: Our findings not only further disclose the lower level of vitamin D in MS patients in comparison with healthy controls, but also support the association between vitamin D and disease severity in MS.
topic 25(OH) vitamin D 3
disease severity
multiple sclerosis
url http://www.ijpvmjournal.net/article.asp?issn=2008-7802;year=2013;volume=4;issue=5;spage=585;epage=591;aulast=Shahbeigi
work_keys_str_mv AT saeedshahbeigi vitamind3concentrationcorrelateswiththeseverityofmultiplesclerosis
AT hosseinpakdaman vitamind3concentrationcorrelateswiththeseverityofmultiplesclerosis
AT seyedmohammadfereshtehnejad vitamind3concentrationcorrelateswiththeseverityofmultiplesclerosis
AT elhamnikravesh vitamind3concentrationcorrelateswiththeseverityofmultiplesclerosis
AT nazaninmirabi vitamind3concentrationcorrelateswiththeseverityofmultiplesclerosis
AT ghazaljalilzadeh vitamind3concentrationcorrelateswiththeseverityofmultiplesclerosis
_version_ 1725557193083715584