Vitamin D3 concentration correlates with the severity of multiple sclerosis
Background: To investigate the possible association between serum 25(OH) vitamin D 3 concentration and the severity of disease in Iranian patients with multiple sclerosis (MS) and to compare this concentration with a matched control group. Methods: This was an analytical cross-sectional study perfo...
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doaj-952733c1f0b243e791ad227ccf56744e2020-11-24T23:25:30ZengWolters Kluwer Medknow PublicationsInternational Journal of Preventive Medicine2008-78022008-82132013-01-0145585591Vitamin D3 concentration correlates with the severity of multiple sclerosisSaeed ShahbeigiHossein PakdamanSeyed-Mohammad FereshtehnejadElham NikraveshNazanin MirabiGhazal JalilzadehBackground: To investigate the possible association between serum 25(OH) vitamin D 3 concentration and the severity of disease in Iranian patients with multiple sclerosis (MS) and to compare this concentration with a matched control group. Methods: This was an analytical cross-sectional study performed at Jondishapour Neurology Clinic in Tehran, Iran. Patients with relapsing-remitting MS were categorized by disease severity: mild [0≤ Expanded Disability Status Scale (EDSS) ≤3], moderate (3.5≤EDSS≤5.5), and severe (6≤EDSS). Serum concentrations of 25(OH) vitamin D 3 , calcium, phosphorus, magnesium, and parathyroid hormone were measured in 98 MS patients and 17 healthy age- and sex-matched controls. Fisher′s exact, Kruskal-Wallis, Mann-Whitney U test, and independent t and Spearman rank correlation tests were used. Results: Serum 25(OH) vitamin D 3 concentration was significantly lower in patients with MS, especially in the severe MS subgroup, compared with healthy controls (P=0.047). There was a statistically significant inverse correlation between 25(OH) vitamin D 3 concentration and EDSS score (P=0.049, R=-0.168 by Spearman rank correlation test), which was observed in women only (P=0.044, R=-0.199). Conclusions: Our findings not only further disclose the lower level of vitamin D in MS patients in comparison with healthy controls, but also support the association between vitamin D and disease severity in MS.http://www.ijpvmjournal.net/article.asp?issn=2008-7802;year=2013;volume=4;issue=5;spage=585;epage=591;aulast=Shahbeigi25(OH) vitamin D 3disease severitymultiple sclerosis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Saeed Shahbeigi Hossein Pakdaman Seyed-Mohammad Fereshtehnejad Elham Nikravesh Nazanin Mirabi Ghazal Jalilzadeh |
spellingShingle |
Saeed Shahbeigi Hossein Pakdaman Seyed-Mohammad Fereshtehnejad Elham Nikravesh Nazanin Mirabi Ghazal Jalilzadeh Vitamin D3 concentration correlates with the severity of multiple sclerosis International Journal of Preventive Medicine 25(OH) vitamin D 3 disease severity multiple sclerosis |
author_facet |
Saeed Shahbeigi Hossein Pakdaman Seyed-Mohammad Fereshtehnejad Elham Nikravesh Nazanin Mirabi Ghazal Jalilzadeh |
author_sort |
Saeed Shahbeigi |
title |
Vitamin D3 concentration correlates with the severity of multiple sclerosis |
title_short |
Vitamin D3 concentration correlates with the severity of multiple sclerosis |
title_full |
Vitamin D3 concentration correlates with the severity of multiple sclerosis |
title_fullStr |
Vitamin D3 concentration correlates with the severity of multiple sclerosis |
title_full_unstemmed |
Vitamin D3 concentration correlates with the severity of multiple sclerosis |
title_sort |
vitamin d3 concentration correlates with the severity of multiple sclerosis |
publisher |
Wolters Kluwer Medknow Publications |
series |
International Journal of Preventive Medicine |
issn |
2008-7802 2008-8213 |
publishDate |
2013-01-01 |
description |
Background: To investigate the possible association between serum 25(OH) vitamin D 3 concentration and the severity of disease in Iranian patients with multiple sclerosis (MS) and to compare this concentration with a matched control group.
Methods: This was an analytical cross-sectional study performed at Jondishapour Neurology Clinic in Tehran, Iran. Patients with relapsing-remitting MS were categorized by disease severity: mild [0≤ Expanded Disability Status Scale (EDSS) ≤3], moderate (3.5≤EDSS≤5.5), and severe (6≤EDSS). Serum concentrations of 25(OH) vitamin D 3 , calcium, phosphorus, magnesium, and parathyroid hormone were measured in 98 MS patients and 17 healthy age- and sex-matched controls. Fisher′s exact, Kruskal-Wallis, Mann-Whitney U test, and independent t and Spearman rank correlation tests were used.
Results: Serum 25(OH) vitamin D 3 concentration was significantly lower in patients with MS, especially in the severe MS subgroup, compared with healthy controls (P=0.047). There was a statistically significant inverse correlation between 25(OH) vitamin D 3 concentration and EDSS score (P=0.049, R=-0.168 by Spearman rank correlation test), which was observed in women only (P=0.044, R=-0.199).
Conclusions: Our findings not only further disclose the lower level of vitamin D in MS patients in comparison with healthy controls, but also support the association between vitamin D and disease severity in MS. |
topic |
25(OH) vitamin D 3 disease severity multiple sclerosis |
url |
http://www.ijpvmjournal.net/article.asp?issn=2008-7802;year=2013;volume=4;issue=5;spage=585;epage=591;aulast=Shahbeigi |
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