Crucial Role of Vitamin D in the Musculoskeletal System
Vitamin D is well known to exert multiple functions in bone biology, autoimmune diseases, cell growth, inflammation or neuromuscular and other immune functions. It is a fat-soluble vitamin present in many foods. It can be endogenously produced by ultraviolet rays from sunlight when the skin is expos...
Main Authors: | , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2016-06-01
|
Series: | Nutrients |
Subjects: | |
Online Access: | http://www.mdpi.com/2072-6643/8/6/319 |
id |
doaj-952af9efd0ca4468ae226faf95c1f1b2 |
---|---|
record_format |
Article |
spelling |
doaj-952af9efd0ca4468ae226faf95c1f1b22020-11-24T22:15:52ZengMDPI AGNutrients2072-66432016-06-018631910.3390/nu8060319nu8060319Crucial Role of Vitamin D in the Musculoskeletal SystemElke Wintermeyer0Christoph Ihle1Sabrina Ehnert2Ulrich Stöckle3Gunnar Ochs4Peter de Zwart5Ingo Flesch6Christian Bahrs7Andreas K. Nussler8Eberhard Karls Universität Tübingen, BG Trauma Center, Siegfried Weller Institut, Schnarrenbergstr. 95, Tübingen D-72076, GermanyEberhard Karls Universität Tübingen, BG Trauma Center, Siegfried Weller Institut, Schnarrenbergstr. 95, Tübingen D-72076, GermanyEberhard Karls Universität Tübingen, BG Trauma Center, Siegfried Weller Institut, Schnarrenbergstr. 95, Tübingen D-72076, GermanyEberhard Karls Universität Tübingen, BG Trauma Center, Siegfried Weller Institut, Schnarrenbergstr. 95, Tübingen D-72076, GermanyEberhard Karls Universität Tübingen, BG Trauma Center, Siegfried Weller Institut, Schnarrenbergstr. 95, Tübingen D-72076, GermanyEberhard Karls Universität Tübingen, BG Trauma Center, Siegfried Weller Institut, Schnarrenbergstr. 95, Tübingen D-72076, GermanyEberhard Karls Universität Tübingen, BG Trauma Center, Siegfried Weller Institut, Schnarrenbergstr. 95, Tübingen D-72076, GermanyEberhard Karls Universität Tübingen, BG Trauma Center, Siegfried Weller Institut, Schnarrenbergstr. 95, Tübingen D-72076, GermanyEberhard Karls Universität Tübingen, BG Trauma Center, Siegfried Weller Institut, Schnarrenbergstr. 95, Tübingen D-72076, GermanyVitamin D is well known to exert multiple functions in bone biology, autoimmune diseases, cell growth, inflammation or neuromuscular and other immune functions. It is a fat-soluble vitamin present in many foods. It can be endogenously produced by ultraviolet rays from sunlight when the skin is exposed to initiate vitamin D synthesis. However, since vitamin D is biologically inert when obtained from sun exposure or diet, it must first be activated in human beings before functioning. The kidney and the liver play here a crucial role by hydroxylation of vitamin D to 25-hydroxyvitamin D in the liver and to 1,25-dihydroxyvitamin D in the kidney. In the past decades, it has been proven that vitamin D deficiency is involved in many diseases. Due to vitamin D’s central role in the musculoskeletal system and consequently the strong negative impact on bone health in cases of vitamin D deficiency, our aim was to underline its importance in bone physiology by summarizing recent findings on the correlation of vitamin D status and rickets, osteomalacia, osteopenia, primary and secondary osteoporosis as well as sarcopenia and musculoskeletal pain. While these diseases all positively correlate with a vitamin D deficiency, there is a great controversy regarding the appropriate vitamin D supplementation as both positive and negative effects on bone mineral density, musculoskeletal pain and incidence of falls are reported.http://www.mdpi.com/2072-6643/8/6/319vitamin Dvitamin D deficiencybone healthmuscle painchronic diseasesupplementation |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Elke Wintermeyer Christoph Ihle Sabrina Ehnert Ulrich Stöckle Gunnar Ochs Peter de Zwart Ingo Flesch Christian Bahrs Andreas K. Nussler |
spellingShingle |
Elke Wintermeyer Christoph Ihle Sabrina Ehnert Ulrich Stöckle Gunnar Ochs Peter de Zwart Ingo Flesch Christian Bahrs Andreas K. Nussler Crucial Role of Vitamin D in the Musculoskeletal System Nutrients vitamin D vitamin D deficiency bone health muscle pain chronic disease supplementation |
author_facet |
Elke Wintermeyer Christoph Ihle Sabrina Ehnert Ulrich Stöckle Gunnar Ochs Peter de Zwart Ingo Flesch Christian Bahrs Andreas K. Nussler |
author_sort |
Elke Wintermeyer |
title |
Crucial Role of Vitamin D in the Musculoskeletal System |
title_short |
Crucial Role of Vitamin D in the Musculoskeletal System |
title_full |
Crucial Role of Vitamin D in the Musculoskeletal System |
title_fullStr |
Crucial Role of Vitamin D in the Musculoskeletal System |
title_full_unstemmed |
Crucial Role of Vitamin D in the Musculoskeletal System |
title_sort |
crucial role of vitamin d in the musculoskeletal system |
publisher |
MDPI AG |
series |
Nutrients |
issn |
2072-6643 |
publishDate |
2016-06-01 |
description |
Vitamin D is well known to exert multiple functions in bone biology, autoimmune diseases, cell growth, inflammation or neuromuscular and other immune functions. It is a fat-soluble vitamin present in many foods. It can be endogenously produced by ultraviolet rays from sunlight when the skin is exposed to initiate vitamin D synthesis. However, since vitamin D is biologically inert when obtained from sun exposure or diet, it must first be activated in human beings before functioning. The kidney and the liver play here a crucial role by hydroxylation of vitamin D to 25-hydroxyvitamin D in the liver and to 1,25-dihydroxyvitamin D in the kidney. In the past decades, it has been proven that vitamin D deficiency is involved in many diseases. Due to vitamin D’s central role in the musculoskeletal system and consequently the strong negative impact on bone health in cases of vitamin D deficiency, our aim was to underline its importance in bone physiology by summarizing recent findings on the correlation of vitamin D status and rickets, osteomalacia, osteopenia, primary and secondary osteoporosis as well as sarcopenia and musculoskeletal pain. While these diseases all positively correlate with a vitamin D deficiency, there is a great controversy regarding the appropriate vitamin D supplementation as both positive and negative effects on bone mineral density, musculoskeletal pain and incidence of falls are reported. |
topic |
vitamin D vitamin D deficiency bone health muscle pain chronic disease supplementation |
url |
http://www.mdpi.com/2072-6643/8/6/319 |
work_keys_str_mv |
AT elkewintermeyer crucialroleofvitamindinthemusculoskeletalsystem AT christophihle crucialroleofvitamindinthemusculoskeletalsystem AT sabrinaehnert crucialroleofvitamindinthemusculoskeletalsystem AT ulrichstockle crucialroleofvitamindinthemusculoskeletalsystem AT gunnarochs crucialroleofvitamindinthemusculoskeletalsystem AT peterdezwart crucialroleofvitamindinthemusculoskeletalsystem AT ingoflesch crucialroleofvitamindinthemusculoskeletalsystem AT christianbahrs crucialroleofvitamindinthemusculoskeletalsystem AT andreasknussler crucialroleofvitamindinthemusculoskeletalsystem |
_version_ |
1725792612482285568 |