Collagen VI and Hyaluronan: The Common Role in Breast Cancer
Collagen VI and hyaluronan are widely distributed extracellular matrix macromolecules that play a crucial role in tissue development and are highly expressed in cancers. Both hyaluronan and collagen VI are upregulated in breast cancer, generating a microenvironment that promotes tumour progression a...
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Series: | BioMed Research International |
Online Access: | http://dx.doi.org/10.1155/2014/606458 |
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doaj-952bf2dc5fe44a4f91d3f8ed920c2c012020-11-25T00:16:57ZengHindawi LimitedBioMed Research International2314-61332314-61412014-01-01201410.1155/2014/606458606458Collagen VI and Hyaluronan: The Common Role in Breast CancerEvgenia Karousou0Maria Luisa D'Angelo1Katerina Kouvidi2Davide Vigetti3Manuela Viola4Dragana Nikitovic5Giancarlo De Luca6Alberto Passi7Department of Surgery and Morphological Sciences, University of Insubria, Via J. H. Dunant 5, 21100 Varese, ItalyDepartment of Surgery and Morphological Sciences, University of Insubria, Via J. H. Dunant 5, 21100 Varese, ItalyDepartment of Histology-Embryology, University of Crete, 71003 Heraklion, GreeceDepartment of Surgery and Morphological Sciences, University of Insubria, Via J. H. Dunant 5, 21100 Varese, ItalyDepartment of Surgery and Morphological Sciences, University of Insubria, Via J. H. Dunant 5, 21100 Varese, ItalyDepartment of Histology-Embryology, University of Crete, 71003 Heraklion, GreeceDepartment of Surgery and Morphological Sciences, University of Insubria, Via J. H. Dunant 5, 21100 Varese, ItalyDepartment of Surgery and Morphological Sciences, University of Insubria, Via J. H. Dunant 5, 21100 Varese, ItalyCollagen VI and hyaluronan are widely distributed extracellular matrix macromolecules that play a crucial role in tissue development and are highly expressed in cancers. Both hyaluronan and collagen VI are upregulated in breast cancer, generating a microenvironment that promotes tumour progression and metastasis. A growing number of studies show that these two molecules are involved in inflammation and angiogenesis by recruiting macrophages and endothelial cells, respectively. Additionally, collagen VI induces epithelial-mesenchymal transition that is correlated to increased synthesis of hyaluronan in mammary cells. Hyaluronan has also a specific role in cellular functions that depends mainly on the size of the polymer, whereas the effect of collagen VI in tumour progression may be the result of the intact molecule or the C5 peptide of α3(VI) chain, known as endotrophin. Collectively, these findings strongly support the parallel role of these molecules in tumour progression and suggest that they may be used as prognostic factors for the breast cancer treatment.http://dx.doi.org/10.1155/2014/606458 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Evgenia Karousou Maria Luisa D'Angelo Katerina Kouvidi Davide Vigetti Manuela Viola Dragana Nikitovic Giancarlo De Luca Alberto Passi |
spellingShingle |
Evgenia Karousou Maria Luisa D'Angelo Katerina Kouvidi Davide Vigetti Manuela Viola Dragana Nikitovic Giancarlo De Luca Alberto Passi Collagen VI and Hyaluronan: The Common Role in Breast Cancer BioMed Research International |
author_facet |
Evgenia Karousou Maria Luisa D'Angelo Katerina Kouvidi Davide Vigetti Manuela Viola Dragana Nikitovic Giancarlo De Luca Alberto Passi |
author_sort |
Evgenia Karousou |
title |
Collagen VI and Hyaluronan: The Common Role in Breast Cancer |
title_short |
Collagen VI and Hyaluronan: The Common Role in Breast Cancer |
title_full |
Collagen VI and Hyaluronan: The Common Role in Breast Cancer |
title_fullStr |
Collagen VI and Hyaluronan: The Common Role in Breast Cancer |
title_full_unstemmed |
Collagen VI and Hyaluronan: The Common Role in Breast Cancer |
title_sort |
collagen vi and hyaluronan: the common role in breast cancer |
publisher |
Hindawi Limited |
series |
BioMed Research International |
issn |
2314-6133 2314-6141 |
publishDate |
2014-01-01 |
description |
Collagen VI and hyaluronan are widely distributed extracellular matrix macromolecules that play a crucial role in tissue development and are highly expressed in cancers. Both hyaluronan and collagen VI are upregulated in breast cancer, generating a microenvironment that promotes tumour progression and metastasis. A growing number of studies show that these two molecules are involved in inflammation and angiogenesis by recruiting macrophages and endothelial cells, respectively. Additionally, collagen VI induces epithelial-mesenchymal transition that is correlated to increased synthesis of hyaluronan in mammary cells. Hyaluronan has also a specific role in cellular functions that depends mainly on the size of the polymer, whereas the effect of collagen VI in tumour progression may be the result of the intact molecule or the C5 peptide of α3(VI) chain, known as endotrophin. Collectively, these findings strongly support the parallel role of these molecules in tumour progression and suggest that they may be used as prognostic factors for the breast cancer treatment. |
url |
http://dx.doi.org/10.1155/2014/606458 |
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