Fused isoselenazolium salts suppress breast cancer cell growth by dramatic increase in pyruvate-dependent mitochondrial ROS production
Abstract The development of targeted drugs for the treatment of cancer remains an unmet medical need. This study was designed to investigate the mechanism underlying breast cancer cell growth suppression caused by fused isoselenazolium salts. The ability to suppress the proliferation of malignant an...
Main Authors: | Marina Makrecka-Kuka, Pavels Dimitrijevs, Ilona Domracheva, Kristaps Jaudzems, Maija Dambrova, Pavel Arsenyan |
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Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2020-12-01
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Series: | Scientific Reports |
Online Access: | https://doi.org/10.1038/s41598-020-78620-8 |
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