Reduced free ubiquitin levels and proteasome activity in cultured neurons and brain tissues treated with amyloid beta aggregates

Reduced free ubiquitin levels and proteasome activity in cultured neurons and brain tissues treated with amyloid beta aggregates

Abstract Neurodegenerative diseases are characterized by progressive cognitive decline and the loss of neurons in the central nervous system; many are also characterized by abnormal aggregation of misfolded proteins. Ubiquitin (Ub) is a eukaryotic protein that plays pivotal roles in protein degradat...

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Bibliographic Details
Main Authors: Chul-Woo Park, Byung-Kwon Jung, Kwon-Yul Ryu
Format: Article
Language:English
Published: BMC 2020-06-01
Series:Molecular Brain
Subjects:
Ubiquitin
Amyloid beta
Primary neuron
Mouse brain slice
Proteasome activity
Online Access:http://link.springer.com/article/10.1186/s13041-020-00632-2

Internet

http://link.springer.com/article/10.1186/s13041-020-00632-2

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