Error-free and error-prone DNA repair gene expression data through reprogramming and passage in human iPS cells

Error-free and error-prone DNA repair gene expression data through reprogramming and passage in human iPS cells

We recently found that DNA repair-related gene expression could be altered by reprogramming as well as the increased expression of genes that accurately convey genomic information, such as homologous recombination (HR) and mismatch repair (MMR), and the decreased expression of error-prone translesio...

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Main Authors: Yasuhide Yoshimura, Daisuke Okuzaki
Format: Article
Language:English
Published: Elsevier 2020-04-01
Series:Data in Brief
Online Access:http://www.sciencedirect.com/science/article/pii/S2352340920301220
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spelling doaj-9531b8358d4b41b99c09abd9bd5cdb502020-11-25T03:54:25ZengElsevierData in Brief2352-34092020-04-0129Error-free and error-prone DNA repair gene expression data through reprogramming and passage in human iPS cellsYasuhide Yoshimura0Daisuke Okuzaki1Division of Gene Therapy Science, Department of Genome Biology, Graduate School of Medicine, Osaka University, Japan; Corresponding author. Division of Gene Therapy Science, Department of Genome Biology, Graduate School of Medicine, Osaka University, Japan.Genome Information Research Center, Research Institute for Microbial Diseases, Osaka University, JapanWe recently found that DNA repair-related gene expression could be altered by reprogramming as well as the increased expression of genes that accurately convey genomic information, such as homologous recombination (HR) and mismatch repair (MMR), and the decreased expression of error-prone translesion synthesis (TLS) polymerase. Here, we confirmed this change in expression in another cell-line and found that such alteration was maintained by overlapping passages as well as OCT3/4 and NANOG. Our findings suggest that changes in the expression of DNA repair-related genes associated with reprogramming and their maintenance can be novel indicators of the quality control of the cells exhibiting pluripotency. Keywords: DNA repair, PARP, RAD51, BLM, Homologous recombination, Mismatch repair, Reprogramminghttp://www.sciencedirect.com/science/article/pii/S2352340920301220
collection DOAJ
language English
format Article
sources DOAJ
author Yasuhide Yoshimura
Daisuke Okuzaki
spellingShingle Yasuhide Yoshimura
Daisuke Okuzaki
Error-free and error-prone DNA repair gene expression data through reprogramming and passage in human iPS cells
Data in Brief
author_facet Yasuhide Yoshimura
Daisuke Okuzaki
author_sort Yasuhide Yoshimura
title Error-free and error-prone DNA repair gene expression data through reprogramming and passage in human iPS cells
title_short Error-free and error-prone DNA repair gene expression data through reprogramming and passage in human iPS cells
title_full Error-free and error-prone DNA repair gene expression data through reprogramming and passage in human iPS cells
title_fullStr Error-free and error-prone DNA repair gene expression data through reprogramming and passage in human iPS cells
title_full_unstemmed Error-free and error-prone DNA repair gene expression data through reprogramming and passage in human iPS cells
title_sort error-free and error-prone dna repair gene expression data through reprogramming and passage in human ips cells
publisher Elsevier
series Data in Brief
issn 2352-3409
publishDate 2020-04-01
description We recently found that DNA repair-related gene expression could be altered by reprogramming as well as the increased expression of genes that accurately convey genomic information, such as homologous recombination (HR) and mismatch repair (MMR), and the decreased expression of error-prone translesion synthesis (TLS) polymerase. Here, we confirmed this change in expression in another cell-line and found that such alteration was maintained by overlapping passages as well as OCT3/4 and NANOG. Our findings suggest that changes in the expression of DNA repair-related genes associated with reprogramming and their maintenance can be novel indicators of the quality control of the cells exhibiting pluripotency. Keywords: DNA repair, PARP, RAD51, BLM, Homologous recombination, Mismatch repair, Reprogramming
url http://www.sciencedirect.com/science/article/pii/S2352340920301220
work_keys_str_mv AT yasuhideyoshimura errorfreeanderrorpronednarepairgeneexpressiondatathroughreprogrammingandpassageinhumanipscells
AT daisukeokuzaki errorfreeanderrorpronednarepairgeneexpressiondatathroughreprogrammingandpassageinhumanipscells
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