Transient opening of trimeric prefusion RSV F proteins
The respiratory syncytial virus (RSV) F glycoprotein forms a trimeric complex and mediates viral entry. Using structures of RSV F in complex with antibodies, Gilman et al. here show a breathing motion of the prefusion conformation of F, resulting in transient opening of the trimeric complex in solut...
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| Format: | Article |
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Nature Publishing Group
2019-05-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-09807-5 |
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doaj-9532301d0812415caee29f9be8ded0472021-05-11T12:09:20ZengNature Publishing GroupNature Communications2041-17232019-05-0110111310.1038/s41467-019-09807-5Transient opening of trimeric prefusion RSV F proteinsMorgan S. A. Gilman0Polina Furmanova-Hollenstein1Gabriel Pascual2Angélique B. van ‘t Wout3Johannes P. M. Langedijk4Jason S. McLellan5Department of Biochemistry and Cell Biology, Geisel School of Medicine at DartmouthJanssen Infectious Diseases and VaccinesJanssen Immunosciences, World Without Disease AcceleratorJanssen Prevention Center, Janssen Vaccines & Prevention B.VJanssen Infectious Diseases and VaccinesDepartment of Molecular Biosciences, University of Texas at AustinThe respiratory syncytial virus (RSV) F glycoprotein forms a trimeric complex and mediates viral entry. Using structures of RSV F in complex with antibodies, Gilman et al. here show a breathing motion of the prefusion conformation of F, resulting in transient opening of the trimeric complex in solution and on the cell surface.https://doi.org/10.1038/s41467-019-09807-5 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Morgan S. A. Gilman Polina Furmanova-Hollenstein Gabriel Pascual Angélique B. van ‘t Wout Johannes P. M. Langedijk Jason S. McLellan |
| spellingShingle |
Morgan S. A. Gilman Polina Furmanova-Hollenstein Gabriel Pascual Angélique B. van ‘t Wout Johannes P. M. Langedijk Jason S. McLellan Transient opening of trimeric prefusion RSV F proteins Nature Communications |
| author_facet |
Morgan S. A. Gilman Polina Furmanova-Hollenstein Gabriel Pascual Angélique B. van ‘t Wout Johannes P. M. Langedijk Jason S. McLellan |
| author_sort |
Morgan S. A. Gilman |
| title |
Transient opening of trimeric prefusion RSV F proteins |
| title_short |
Transient opening of trimeric prefusion RSV F proteins |
| title_full |
Transient opening of trimeric prefusion RSV F proteins |
| title_fullStr |
Transient opening of trimeric prefusion RSV F proteins |
| title_full_unstemmed |
Transient opening of trimeric prefusion RSV F proteins |
| title_sort |
transient opening of trimeric prefusion rsv f proteins |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2019-05-01 |
| description |
The respiratory syncytial virus (RSV) F glycoprotein forms a trimeric complex and mediates viral entry. Using structures of RSV F in complex with antibodies, Gilman et al. here show a breathing motion of the prefusion conformation of F, resulting in transient opening of the trimeric complex in solution and on the cell surface. |
| url |
https://doi.org/10.1038/s41467-019-09807-5 |
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