Discovering the genes mediating the interactions between chronic respiratory diseases in the human interactome

Complex diseases often share genetic determinants and symptoms, but the mechanistic basis of disease interactions remains elusive. Here, the authors propose a network topological measure to identify proteins linking complex diseases in the interactome, and identify mediators between COPD and asthma.

Bibliographic Details
Main Authors:	Enrico Maiorino, Seung Han Baek, Feng Guo, Xiaobo Zhou, Parul H. Kothari, Edwin K. Silverman, Albert-László Barabási, Scott T. Weiss, Benjamin A. Raby, Amitabh Sharma
Format:	Article
Language:	English
Published:	Nature Publishing Group 2020-02-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-020-14600-w

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spelling	doaj-95353d29e28049fbaf770305d65dd8a52021-05-11T08:48:31ZengNature Publishing GroupNature Communications2041-17232020-02-0111111410.1038/s41467-020-14600-wDiscovering the genes mediating the interactions between chronic respiratory diseases in the human interactomeEnrico Maiorino0Seung Han Baek1Feng Guo2Xiaobo Zhou3Parul H. Kothari4Edwin K. Silverman5Albert-László Barabási6Scott T. Weiss7Benjamin A. Raby8Amitabh Sharma9Channing Division of Network Medicine, Brigham and Women’s Hospital, Harvard Medical SchoolChanning Division of Network Medicine, Brigham and Women’s Hospital, Harvard Medical SchoolChanning Division of Network Medicine, Brigham and Women’s Hospital, Harvard Medical SchoolChanning Division of Network Medicine, Brigham and Women’s Hospital, Harvard Medical SchoolChanning Division of Network Medicine, Brigham and Women’s Hospital, Harvard Medical SchoolChanning Division of Network Medicine, Brigham and Women’s Hospital, Harvard Medical SchoolChanning Division of Network Medicine, Brigham and Women’s Hospital, Harvard Medical SchoolChanning Division of Network Medicine, Brigham and Women’s Hospital, Harvard Medical SchoolChanning Division of Network Medicine, Brigham and Women’s Hospital, Harvard Medical SchoolChanning Division of Network Medicine, Brigham and Women’s Hospital, Harvard Medical SchoolComplex diseases often share genetic determinants and symptoms, but the mechanistic basis of disease interactions remains elusive. Here, the authors propose a network topological measure to identify proteins linking complex diseases in the interactome, and identify mediators between COPD and asthma.https://doi.org/10.1038/s41467-020-14600-w
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Enrico Maiorino Seung Han Baek Feng Guo Xiaobo Zhou Parul H. Kothari Edwin K. Silverman Albert-László Barabási Scott T. Weiss Benjamin A. Raby Amitabh Sharma
spellingShingle	Enrico Maiorino Seung Han Baek Feng Guo Xiaobo Zhou Parul H. Kothari Edwin K. Silverman Albert-László Barabási Scott T. Weiss Benjamin A. Raby Amitabh Sharma Discovering the genes mediating the interactions between chronic respiratory diseases in the human interactome Nature Communications
author_facet	Enrico Maiorino Seung Han Baek Feng Guo Xiaobo Zhou Parul H. Kothari Edwin K. Silverman Albert-László Barabási Scott T. Weiss Benjamin A. Raby Amitabh Sharma
author_sort	Enrico Maiorino
title	Discovering the genes mediating the interactions between chronic respiratory diseases in the human interactome
title_short	Discovering the genes mediating the interactions between chronic respiratory diseases in the human interactome
title_full	Discovering the genes mediating the interactions between chronic respiratory diseases in the human interactome
title_fullStr	Discovering the genes mediating the interactions between chronic respiratory diseases in the human interactome
title_full_unstemmed	Discovering the genes mediating the interactions between chronic respiratory diseases in the human interactome
title_sort	discovering the genes mediating the interactions between chronic respiratory diseases in the human interactome
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2020-02-01
description	Complex diseases often share genetic determinants and symptoms, but the mechanistic basis of disease interactions remains elusive. Here, the authors propose a network topological measure to identify proteins linking complex diseases in the interactome, and identify mediators between COPD and asthma.
url	https://doi.org/10.1038/s41467-020-14600-w
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Discovering the genes mediating the interactions between chronic respiratory diseases in the human interactome

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