A Reassessment of Copy Number Variations in Congenital Heart Defects: Picturing the Whole Genome

A Reassessment of Copy Number Variations in Congenital Heart Defects: Picturing the Whole Genome

Copy number variations (CNVs) can modulate phenotypes by affecting protein-coding sequences directly or through interference of gene expression. Recent studies in cancer and limb defects pinpointed the relevance of non-coding gene regulatory elements such as long non-coding RNAs (lncRNAs) and topolo...

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Bibliographic Details
Main Authors: Ilse Meerschaut, Sarah Vergult, Annelies Dheedene, Björn Menten, Katya De Groote, Hans De Wilde, Laura Muiño Mosquera, Joseph Panzer, Kristof Vandekerckhove, Paul J. Coucke, Daniël De Wolf, Bert Callewaert
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Genes
Subjects:
copy number variations
congenital heart defects
protein-coding genes
non-coding elements
topology associated domains
Online Access:https://www.mdpi.com/2073-4425/12/7/1048

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