Integrative genomic analysis of adult mixed phenotype acute leukemia delineates lineage associated molecular subtypes

Mixed phenotype acute leukemia (MPAL) is a rare leukemia that presents both myeloid and lymphoid markers on blasts. Here the authors perform genomic analysis to show MPAL involves genetic and epigenetic heterogeneity and is genetically distinct from AML, B-ALL, and T-ALL.

Bibliographic Details
Main Authors:	Koichi Takahashi, Feng Wang, Kiyomi Morita, Yuanqing Yan, Peter Hu, Pei Zhao, Abdallah Abou Zhar, Chang Jiun Wu, Curtis Gumbs, Latasha Little, Samantha Tippen, Rebecca Thornton, Marcus Coyle, Marisela Mendoza, Erika Thompson, Jianhua Zhang, Courtney D. DiNardo, Nitin Jain, Farhad Ravandi, Jorge E. Cortes, Guillermo Garcia-Manero, Steven Kornblau, Michael Andreeff, Elias Jabbour, Carlos Bueso-Ramos, Akifumi Takaori-Kondo, Marina Konopleva, Keyur Patel, Hagop Kantarjian, P. Andrew Futreal
Format:	Article
Language:	English
Published:	Nature Publishing Group 2018-07-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-018-04924-z

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spelling	doaj-953fd20186754223976bbb7a89f2b1cf2021-05-11T10:34:30ZengNature Publishing GroupNature Communications2041-17232018-07-019111210.1038/s41467-018-04924-zIntegrative genomic analysis of adult mixed phenotype acute leukemia delineates lineage associated molecular subtypesKoichi Takahashi0Feng Wang1Kiyomi Morita2Yuanqing Yan3Peter Hu4Pei Zhao5Abdallah Abou Zhar6Chang Jiun Wu7Curtis Gumbs8Latasha Little9Samantha Tippen10Rebecca Thornton11Marcus Coyle12Marisela Mendoza13Erika Thompson14Jianhua Zhang15Courtney D. DiNardo16Nitin Jain17Farhad Ravandi18Jorge E. Cortes19Guillermo Garcia-Manero20Steven Kornblau21Michael Andreeff22Elias Jabbour23Carlos Bueso-Ramos24Akifumi Takaori-Kondo25Marina Konopleva26Keyur Patel27Hagop Kantarjian28P. Andrew Futreal29Department of Leukemia, The University of Texas MD Anderson Cancer CenterDepartment of Genomic Medicine, The University of Texas MD Anderson Cancer CenterDepartment of Leukemia, The University of Texas MD Anderson Cancer CenterDepartment of Biostatistics, The University of Texas MD Anderson Cancer CenterDiagnostic Genetics Program, The University of Texas MD Anderson Cancer CenterDiagnostic Genetics Program, The University of Texas MD Anderson Cancer CenterDepartment of Leukemia, The University of Texas MD Anderson Cancer CenterDepartment of Genomic Medicine, The University of Texas MD Anderson Cancer CenterDepartment of Genomic Medicine, The University of Texas MD Anderson Cancer CenterDepartment of Genomic Medicine, The University of Texas MD Anderson Cancer CenterDepartment of Genomic Medicine, The University of Texas MD Anderson Cancer CenterDepartment of Genomic Medicine, The University of Texas MD Anderson Cancer CenterDepartment of Genomic Medicine, The University of Texas MD Anderson Cancer CenterDepartment of Genetics, The University of Texas MD Anderson Cancer CenterDepartment of Genetics, The University of Texas MD Anderson Cancer CenterDepartment of Genomic Medicine, The University of Texas MD Anderson Cancer CenterDepartment of Leukemia, The University of Texas MD Anderson Cancer CenterDepartment of Leukemia, The University of Texas MD Anderson Cancer CenterDepartment of Leukemia, The University of Texas MD Anderson Cancer CenterDepartment of Leukemia, The University of Texas MD Anderson Cancer CenterDepartment of Leukemia, The University of Texas MD Anderson Cancer CenterDepartment of Leukemia, The University of Texas MD Anderson Cancer CenterDepartment of Leukemia, The University of Texas MD Anderson Cancer CenterDepartment of Leukemia, The University of Texas MD Anderson Cancer CenterDepartment of Hematopathology, The University of Texas MD Anderson Cancer CenterDepartment of Hematology and Oncology, Graduate School of Medicine, Kyoto UniversityDepartment of Leukemia, The University of Texas MD Anderson Cancer CenterDepartment of Hematopathology, The University of Texas MD Anderson Cancer CenterDepartment of Leukemia, The University of Texas MD Anderson Cancer CenterDepartment of Genomic Medicine, The University of Texas MD Anderson Cancer CenterMixed phenotype acute leukemia (MPAL) is a rare leukemia that presents both myeloid and lymphoid markers on blasts. Here the authors perform genomic analysis to show MPAL involves genetic and epigenetic heterogeneity and is genetically distinct from AML, B-ALL, and T-ALL.https://doi.org/10.1038/s41467-018-04924-z
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Koichi Takahashi Feng Wang Kiyomi Morita Yuanqing Yan Peter Hu Pei Zhao Abdallah Abou Zhar Chang Jiun Wu Curtis Gumbs Latasha Little Samantha Tippen Rebecca Thornton Marcus Coyle Marisela Mendoza Erika Thompson Jianhua Zhang Courtney D. DiNardo Nitin Jain Farhad Ravandi Jorge E. Cortes Guillermo Garcia-Manero Steven Kornblau Michael Andreeff Elias Jabbour Carlos Bueso-Ramos Akifumi Takaori-Kondo Marina Konopleva Keyur Patel Hagop Kantarjian P. Andrew Futreal
spellingShingle	Koichi Takahashi Feng Wang Kiyomi Morita Yuanqing Yan Peter Hu Pei Zhao Abdallah Abou Zhar Chang Jiun Wu Curtis Gumbs Latasha Little Samantha Tippen Rebecca Thornton Marcus Coyle Marisela Mendoza Erika Thompson Jianhua Zhang Courtney D. DiNardo Nitin Jain Farhad Ravandi Jorge E. Cortes Guillermo Garcia-Manero Steven Kornblau Michael Andreeff Elias Jabbour Carlos Bueso-Ramos Akifumi Takaori-Kondo Marina Konopleva Keyur Patel Hagop Kantarjian P. Andrew Futreal Integrative genomic analysis of adult mixed phenotype acute leukemia delineates lineage associated molecular subtypes Nature Communications
author_facet	Koichi Takahashi Feng Wang Kiyomi Morita Yuanqing Yan Peter Hu Pei Zhao Abdallah Abou Zhar Chang Jiun Wu Curtis Gumbs Latasha Little Samantha Tippen Rebecca Thornton Marcus Coyle Marisela Mendoza Erika Thompson Jianhua Zhang Courtney D. DiNardo Nitin Jain Farhad Ravandi Jorge E. Cortes Guillermo Garcia-Manero Steven Kornblau Michael Andreeff Elias Jabbour Carlos Bueso-Ramos Akifumi Takaori-Kondo Marina Konopleva Keyur Patel Hagop Kantarjian P. Andrew Futreal
author_sort	Koichi Takahashi
title	Integrative genomic analysis of adult mixed phenotype acute leukemia delineates lineage associated molecular subtypes
title_short	Integrative genomic analysis of adult mixed phenotype acute leukemia delineates lineage associated molecular subtypes
title_full	Integrative genomic analysis of adult mixed phenotype acute leukemia delineates lineage associated molecular subtypes
title_fullStr	Integrative genomic analysis of adult mixed phenotype acute leukemia delineates lineage associated molecular subtypes
title_full_unstemmed	Integrative genomic analysis of adult mixed phenotype acute leukemia delineates lineage associated molecular subtypes
title_sort	integrative genomic analysis of adult mixed phenotype acute leukemia delineates lineage associated molecular subtypes
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2018-07-01
description	Mixed phenotype acute leukemia (MPAL) is a rare leukemia that presents both myeloid and lymphoid markers on blasts. Here the authors perform genomic analysis to show MPAL involves genetic and epigenetic heterogeneity and is genetically distinct from AML, B-ALL, and T-ALL.
url	https://doi.org/10.1038/s41467-018-04924-z
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Integrative genomic analysis of adult mixed phenotype acute leukemia delineates lineage associated molecular subtypes

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