Interleukin-17 Reduces βENaC via MAPK Signaling in Vascular Smooth Muscle Cells

Interleukin-17 Reduces βENaC via MAPK Signaling in Vascular Smooth Muscle Cells

Degenerin proteins, such as the beta epithelial Na<sup>+</sup> channel (βENaC), are essential in the intracellular signaling of pressure-induced constriction, an important vascular smooth muscle cell (VSMC) function. While certain cytokines reduce ENaC protein in epithelial tissue, it is...

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Bibliographic Details
Main Authors: Jeremy W. Duncan, Joey P. Granger, Michael J. Ryan, Heather A. Drummond
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:International Journal of Molecular Sciences
Subjects:
IL-17
degenerins
beta-ENaC
VSMCs
p38MAPK
JNK
Online Access:https://www.mdpi.com/1422-0067/21/8/2953

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