Inhibitory Effects of Genistein on Vascular Smooth Muscle Cell Proliferation Induced by Ox-LDL: Role of BKCa Channels

Inhibitory Effects of Genistein on Vascular Smooth Muscle Cell Proliferation Induced by Ox-LDL: Role of BKCa Channels

Background. Oxidized low-density lipoprotein (Ox-LDL) is a crucial pathogenic factor for vascular diseases, which can induce the proliferation of vascular smooth muscle cells (VSMCs). Genistein is the main component of soybean isoflavone. Genistein has a variety of pharmacological properties in the...

Full description

Bibliographic Details
Main Authors:	Bing Bai, Nanjuan Lu, Wei Zhang, Jinghan Lin, Tingting Zhao, Shanshan Zhou, Elona Khasanova, Liming Zhang
Format:	Article
Language:	English
Published:	Hindawi Limited 2020-01-01
Series:	Analytical Cellular Pathology
Online Access:	http://dx.doi.org/10.1155/2020/8895449

Similar Items

Melatonin inhibits ox-LDL-induced proliferation of vascular smooth muscle cells
by: TANG Yang, et al.
Published: (2021-09-01)

Ellagic acid inhibit vascular smooth muscle cell proliferation and apoptosis induced by ox-LDL
by: 曾瓊瑤
Published: (2004)

Early Transcriptomic Response to LDL and oxLDL in Human Vascular Smooth Muscle Cells.
by: Salvador Damián-Zamacona, et al.
Published: (2016-01-01)

The Mechanisms of Genistein in Diabetic Vascular Smooth Muscle Cell Proliferation and Migration：A ReviewThe Mechanisms of Genistein in Diabetic Vascular Smooth Muscle Cell proliferation and Migration：A Reviewhe Mechanisms of Genistein in Diabetic Vasc
by: Kao Ya-Chun, et al.
Published: (2005)

The effects of SOD and catalase overexpression on the proliferation of oxLDL-treated human aortic smooth muscle cells
by: Ting-Hui Chu, et al.
Published: (2003)

Role of BKCa in Stretch-Induced Relaxation of Colonic Smooth Muscle
by: Jie Ren, et al.
Published: (2016-01-01)

Tanshinone IIA suppresses the progression of atherosclerosis by inhibiting the apoptosis of vascular smooth muscle cells and the proliferation and migration of macrophages induced by ox-LDL
by: Baocai Wang, et al.
Published: (2017-04-01)

Downregulation of hsa_circ_0004543 Activates oxLDL-Induced Vascular Endothelial Cell Proliferation and Angiogenesis
by: Lu Han, et al.
Published: (2021-03-01)

c-Ski inhibits autophagy of vascular smooth muscle cells induced by oxLDL and PDGF.
by: Jun Li, et al.
Published: (2014-01-01)

The effect of antioxidant enzymes on the proliferation of oxLDL-treated human aortic smooth muscle cells and its underlying mechanism
by: Meng-Chun Shih, et al.
Published: (2004)

The effect of ox-LDL on the formation of DAG and activation of PKC in smooth muscle cell
by: Huey-Je Jong, et al.
Published: (1993)

MITOCHONDRIAL BKCa CHANNEL
by: Enrique eBalderas, et al.
Published: (2015-03-01)

H19 knockdown suppresses proliferation and induces apoptosis by regulating miR-148b/WNT/β-catenin in ox-LDL -stimulated vascular smooth muscle cells
by: Lei Zhang, et al.
Published: (2018-02-01)

KMUP-1 activates BKCa channels in pulmonary artery smooth muscle cells
by: Chang-Ling Kao, et al.
Published: (2007)

CircMTO1 inhibits ox-LDL-stimulated vascular smooth muscle cell proliferation and migration via regulating the miR-182-5p/RASA1 axis
by: Ningning Ji, et al.
Published: (2021-07-01)

Effect of the oxidized-LDL on the proliferation of smooth muscle cells
by: ZHENG, MEI-LING, et al.
Published: (1992)

Long non-coding RNA MIAT regulates ox-LDL-induced cell proliferation, migration and invasion by miR-641/STIM1 axis in human vascular smooth muscle cells
by: Gang Ma, et al.
Published: (2021-05-01)

Mechanisms of Trained Innate Immunity in oxLDL Primed Human Coronary Smooth Muscle Cells
by: Lucia Schnack, et al.
Published: (2019-01-01)

Autoantibodies to OxLDL fail to alter the clearance of injected OxLDL in apolipoprotein E-deficient mice
by: Catherine A. Reardon, et al.
Published: (2004-07-01)

Dopamine D1-Like Receptors Suppress the Proliferation of Macrophages Induced by Ox-LDL
by: Yonggang Yao, et al.
Published: (2016-01-01)

LOX-1, OxLDL, and Atherosclerosis
by: Angela Pirillo, et al.
Published: (2013-01-01)

Inhibition of macrophage metabolism by oxLDL
by: Katouah, Hanadi
Published: (2013)

Elucidation of the Role of Lectin-Like oxLDL Receptor-1 in the Metabolic Responses of Macrophages to Human oxLDL
by: Danielle W. Kimmel, et al.
Published: (2017-01-01)

Anticorpos contra LDL-ox e síndrome coronariana aguda Anticuerpos contra LDL-ox y síndrome coronario agudo Antibodies against OxLDL and acute coronary syndrome
by: Ana Maria Brito Medeiros, et al.
Published: (2010-07-01)

Effect of Endomorphins on HUVECs Treated by ox-LDL and Its Related Mechanisms
by: Juan Zhao, et al.
Published: (2016-01-01)

oxLDL and eLDL Induced Membrane Microdomains in Human Macrophages.
by: Stefan Wallner, et al.
Published: (2016-01-01)

Generation and testing of an anti-idiotype that acts as a surrogate antigen for oxidized LDL (OxLDL) in serological studies measuring anti-OxLDL antibodies
by: Chang, Shang-Hung
Published: (2010)

Ox-LDL-activated Protein Kinase B/Akt via Transactivation of EGF and PDGF Receptors in Rat Vascular Smooth Muscle Cells
by: Ming-Wei Chien, et al.
Published: (2002)

Genistein and Magnolol protect against smooth muscle cell proliferation by upregulating heme oxygenase-1
by: Ji-Fang Chen, et al.
Published: (2010)

Caveolin-1 Limits the Contribution of BKCa Channel to MCF-7 Breast Cancer Cell Proliferation and Invasion
by: Cheng Du, et al.
Published: (2014-11-01)

Long noncoding RNA CASC2 inhibits ox-LDL-mediated vascular smooth muscle cells proliferation and migration via the regulation of miR-532-3p/PAPD5
by: Chenjing Wang, et al.
Published: (2020-07-01)

Proliferation of Vascular Smooth Muscle Cells under ox-LDL Is Regulated by Alismatis rhizoma Decoction via InhibitingERK1/2 and miR-17∼92a Cluster Activation
by: Julian Shen, et al.
Published: (2020-01-01)

BKCa channel dysfunction in neurological diseases
by: Prosper eN'Gouemo
Published: (2014-09-01)

Mechanism of genistein in the regulation of pancreatic beta-cell proliferation
by: Zhang, Wen
Published: (2014)

Calpain-1 Mediated Disorder of Pyrophosphate Metabolism Contributes to Vascular Calcification Induced by oxLDL.
by: Futian Tang, et al.
Published: (2015-01-01)

OxLDL induces mitogen-activated protein kinase activation mediated via PI3-kinase/Akt in vascular smooth muscle cells
by: Ming-Wei Chien, et al.
Published: (2003-09-01)

Polysaccharides from Poria cocos (PCP) inhibits ox-LDL-induced vascular smooth muscle cells proliferation and migration by suppressing TLR4/NF-κB p65 signaling pathway
by: Weifeng Li, et al.
Published: (2019-09-01)

The association between serum levels of oxLDL-lgG and oxLDL-lgM autoantibody with adult acute myeloblastic leukaemia
by: Cui Jia, et al.
Published: (2010-01-01)

LOX-1 augments oxLDL uptake by lysoPC-stimulated murine macrophages but is not required for oxLDL clearance from plasma
by: David F. Schaeffer, et al.
Published: (2009-08-01)

Inhibitory Effects and Mechanisms of Luteolin on Proliferation and Migration of Vascular Smooth Muscle Cells
by: Wanling Wu, et al.
Published: (2013-05-01)

Cannot write session to /tmp/vufind_sessions/sess_ar4ufkjtsmdp4p4q9sq08tesfp