Protein C Gene Mutation in an Older Adult Patient with Clostridium perfringens Septicemia-Related Visceral Vein Thrombosis

Protein C Gene Mutation in an Older Adult Patient with Clostridium perfringens Septicemia-Related Visceral Vein Thrombosis

A 78-year-old Japanese male with Clostridium perfringens septicemia and cholecystitis was found to have thrombosis in the left branch of intrahepatic portal vein as well as superior mesenteric vein. Visceral vein thrombosis (VVT) in this case was associated with protein C deficiency, due to a hetero...

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Bibliographic Details
Main Authors: Kiyoko Kanosue, Satomi Nagaya, Eriko Morishita, Masayoshi Yamanishi, Shinsaku Imashuku
Format: Article
Language:English
Published: Georg Thieme Verlag KG 2021-04-01
Series:TH Open
Subjects:
visceral vein thrombosis
protein c deficiency
clostridium perfringens
septicemia
older adult
Online Access:http://www.thieme-connect.de/DOI/DOI?10.1055/s-0041-1728664
Description
Summary:A 78-year-old Japanese male with Clostridium perfringens septicemia and cholecystitis was found to have thrombosis in the left branch of intrahepatic portal vein as well as superior mesenteric vein. Visceral vein thrombosis (VVT) in this case was associated with protein C deficiency, due to a heterozygous mutation, p. Arg185Met. Our experience emphasizes that VVT, or other thromboembolic events, may occur in later life, triggered by environmental thrombosis risk factors, together with underlying hereditary protein C gene mutation.
ISSN:2512-9465

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