Grape seed proanthocyanidin extract reverses multidrug resistance in HL-60/ADR cells via inhibition of the PI3K/Akt signaling pathway

Grape seed proanthocyanidin extract reverses multidrug resistance in HL-60/ADR cells via inhibition of the PI3K/Akt signaling pathway

Background and purpose: Multidrug resistance (MDR) is a great challenge and obstacle in cancer treatment. It is a common problem in the treatment of acute myeloid leukemia (AML). Whether grape seed proanthocyanidin extract (GSPE) could reverse MDR in patients with AML is still unknown. The aim of th...

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Bibliographic Details
Main Authors:	Ka-Na Lin, Yue-Lian Jiang, Shun-Guo Zhang, Shi-Ying Huang, Hao Li
Format:	Article
Language:	English
Published:	Elsevier 2020-05-01
Series:	Biomedicine & Pharmacotherapy
Subjects:	Grape seed proanthocyanidin extract Drug resistance Multidrug resistance-associated protein 1 ABCC1 Multidrug resistance protein 1 p-glycoprotein
Online Access:	http://www.sciencedirect.com/science/article/pii/S0753332220300755

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