Interactions at engineered graft–tissue interfaces: A review

• Main Authors: Wenzhen Zhu, Xiaolei Nie, Qi Tao, Hang Yao, Dong-An Wang
• Format: Article
• Language: English
• Published: AIP Publishing LLC 2020-09-01
• Series: APL Bioengineering
• Online Access: http://dx.doi.org/10.1063/5.0014519

The interactions at the graft–tissue interfaces are critical for the results of engraftments post-implantation. To improve the success rate of the implantations, as well as the quality of the patients' life, understanding the possible reactions between artificial materials and the host tissues is helpful in designing new generations of material-based grafts aiming at inducing specific responses from surrounding tissues for their own reparation and regeneration. To help researchers understand the complicated interactions that occur after implantations and to promote the development of better-designed grafts with improved biocompatibility and patient responses, in this review, the topics will be discussed from the basic reactions that occur chronologically at the graft–tissue interfaces after implantations to the existing and potential applications of the mechanisms of such reactions in designing of grafts. It offers a chance to bring up-to-date advances in the field and new strategies of controlling the graft–tissue interfaces.