Notch-mediated conversion of activated T cells into stem cell memory-like T cells for adoptive immunotherapy

Tumour-specific T cells can be expandedin vitroand adoptively transferred for therapy, but this strategy is limited by induction of short-lived T cell populations. Here the authors activate Notch signalling in cultured mouse or human T cells, resulting in the production of a long-lived stem cell mem...

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Main Authors:	Taisuke Kondo, Rimpei Morita, Yuumi Okuzono, Hiroko Nakatsukasa, Takashi Sekiya, Shunsuke Chikuma, Takashi Shichita, Mitsuhiro Kanamori, Masato Kubo, Keiko Koga, Takahiro Miyazaki, Yoshiaki Kassai, Akihiko Yoshimura
Format:	Article
Language:	English
Published:	Nature Publishing Group 2017-05-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/ncomms15338

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spelling	doaj-956f24e4dd8a4d5881a8d99fc61d6ef72021-05-11T07:19:42ZengNature Publishing GroupNature Communications2041-17232017-05-018111410.1038/ncomms15338Notch-mediated conversion of activated T cells into stem cell memory-like T cells for adoptive immunotherapyTaisuke Kondo0Rimpei Morita1Yuumi Okuzono2Hiroko Nakatsukasa3Takashi Sekiya4Shunsuke Chikuma5Takashi Shichita6Mitsuhiro Kanamori7Masato Kubo8Keiko Koga9Takahiro Miyazaki10Yoshiaki Kassai11Akihiko Yoshimura12Department of Microbiology and Immunology, Keio University School of MedicineDepartment of Microbiology and Immunology, Keio University School of MedicinePharmaceutical Research Division, Inflammation Drug Discovery Unit, Takeda Pharmaceutical Company LimitedDepartment of Microbiology and Immunology, Keio University School of MedicineDepartment of Microbiology and Immunology, Keio University School of MedicineDepartment of Microbiology and Immunology, Keio University School of MedicineDepartment of Microbiology and Immunology, Keio University School of MedicineDepartment of Microbiology and Immunology, Keio University School of MedicineDivision of Molecular Pathology, Research Institute for Biomedical Science, Tokyo University of SciencePharmaceutical Research Division, Inflammation Drug Discovery Unit, Takeda Pharmaceutical Company LimitedPharmaceutical Research Division, Inflammation Drug Discovery Unit, Takeda Pharmaceutical Company LimitedPharmaceutical Research Division, Inflammation Drug Discovery Unit, Takeda Pharmaceutical Company LimitedDepartment of Microbiology and Immunology, Keio University School of MedicineTumour-specific T cells can be expandedin vitroand adoptively transferred for therapy, but this strategy is limited by induction of short-lived T cell populations. Here the authors activate Notch signalling in cultured mouse or human T cells, resulting in the production of a long-lived stem cell memory T cell population that can fight tumours in mice.https://doi.org/10.1038/ncomms15338
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Taisuke Kondo Rimpei Morita Yuumi Okuzono Hiroko Nakatsukasa Takashi Sekiya Shunsuke Chikuma Takashi Shichita Mitsuhiro Kanamori Masato Kubo Keiko Koga Takahiro Miyazaki Yoshiaki Kassai Akihiko Yoshimura
spellingShingle	Taisuke Kondo Rimpei Morita Yuumi Okuzono Hiroko Nakatsukasa Takashi Sekiya Shunsuke Chikuma Takashi Shichita Mitsuhiro Kanamori Masato Kubo Keiko Koga Takahiro Miyazaki Yoshiaki Kassai Akihiko Yoshimura Notch-mediated conversion of activated T cells into stem cell memory-like T cells for adoptive immunotherapy Nature Communications
author_facet	Taisuke Kondo Rimpei Morita Yuumi Okuzono Hiroko Nakatsukasa Takashi Sekiya Shunsuke Chikuma Takashi Shichita Mitsuhiro Kanamori Masato Kubo Keiko Koga Takahiro Miyazaki Yoshiaki Kassai Akihiko Yoshimura
author_sort	Taisuke Kondo
title	Notch-mediated conversion of activated T cells into stem cell memory-like T cells for adoptive immunotherapy
title_short	Notch-mediated conversion of activated T cells into stem cell memory-like T cells for adoptive immunotherapy
title_full	Notch-mediated conversion of activated T cells into stem cell memory-like T cells for adoptive immunotherapy
title_fullStr	Notch-mediated conversion of activated T cells into stem cell memory-like T cells for adoptive immunotherapy
title_full_unstemmed	Notch-mediated conversion of activated T cells into stem cell memory-like T cells for adoptive immunotherapy
title_sort	notch-mediated conversion of activated t cells into stem cell memory-like t cells for adoptive immunotherapy
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2017-05-01
description	Tumour-specific T cells can be expandedin vitroand adoptively transferred for therapy, but this strategy is limited by induction of short-lived T cell populations. Here the authors activate Notch signalling in cultured mouse or human T cells, resulting in the production of a long-lived stem cell memory T cell population that can fight tumours in mice.
url	https://doi.org/10.1038/ncomms15338
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Notch-mediated conversion of activated T cells into stem cell memory-like T cells for adoptive immunotherapy

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