Broad-Spectrum Antiviral Natural Products from the Marine-Derived <em>Penicillium</em> sp. IMB17-046
A new pyrazine derivative, trypilepyrazinol (<b>1</b>), a new α-pyrone polyketide, (+)-neocitreoviridin (<b>2</b>), and a new ergostane analogue, 3β-hydroxyergosta-8,14,24(28)-trien-7-one (<b>3</b>), were isolated and characterized along with five known compounds...
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doaj-957eb5becd9a4efeac56ed97ea1679a22020-11-25T01:17:12ZengMDPI AGMolecules1420-30492019-08-012415282110.3390/molecules24152821molecules24152821Broad-Spectrum Antiviral Natural Products from the Marine-Derived <em>Penicillium</em> sp. IMB17-046Jiao Li0Yujia Wang1Xiaomeng Hao2Shasha Li3Jia Jia4Yan Guan5Zonggen Peng6Hongkai Bi7Chunling Xiao8Shan Cen9Maoluo Gan10Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, ChinaInstitute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, ChinaInstitute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, ChinaInstitute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, ChinaDepartment of Pathogen Biology, Jiangsu Key Laboratory of Pathogen Biology, Nanjing Medical University, Nanjing 210029, ChinaInstitute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, ChinaInstitute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, ChinaDepartment of Pathogen Biology, Jiangsu Key Laboratory of Pathogen Biology, Nanjing Medical University, Nanjing 210029, ChinaInstitute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, ChinaInstitute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, ChinaInstitute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, ChinaA new pyrazine derivative, trypilepyrazinol (<b>1</b>), a new α-pyrone polyketide, (+)-neocitreoviridin (<b>2</b>), and a new ergostane analogue, 3β-hydroxyergosta-8,14,24(28)-trien-7-one (<b>3</b>), were isolated and characterized along with five known compounds from the marine-derived fungus <i>Penicillium</i> sp. IMB17-046. The structures of these new compounds were determined using spectroscopic data analyses (HRESIMS, 1D- and 2D-NMR), X-ray crystallography analysis, and TDDFT ECD calculation. Compounds <b>1</b> and <b>3</b> exhibited broad-spectrum antiviral activities against different types of viruses, including human immunodeficiency virus (HIV), hepatitis C virus (HCV), and influenza A virus (IAV), with IC<sub>50</sub> values ranging from 0.5 to 7.7 μM. Compounds <b>1</b> and <b>2</b> showed antibacterial activities against <i>Helicobacter pylori</i>, a causative pathogen of various gastric diseases, with minimum inhibitory concentration (MIC) values of 1–16 μg/mL.https://www.mdpi.com/1420-3049/24/15/2821marine fungus<i>Penicillium</i>pyrazine natural productantiviralHIVinfluenza A virus<i>Helicobacter pylori</i> |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jiao Li Yujia Wang Xiaomeng Hao Shasha Li Jia Jia Yan Guan Zonggen Peng Hongkai Bi Chunling Xiao Shan Cen Maoluo Gan |
spellingShingle |
Jiao Li Yujia Wang Xiaomeng Hao Shasha Li Jia Jia Yan Guan Zonggen Peng Hongkai Bi Chunling Xiao Shan Cen Maoluo Gan Broad-Spectrum Antiviral Natural Products from the Marine-Derived <em>Penicillium</em> sp. IMB17-046 Molecules marine fungus <i>Penicillium</i> pyrazine natural product antiviral HIV influenza A virus <i>Helicobacter pylori</i> |
author_facet |
Jiao Li Yujia Wang Xiaomeng Hao Shasha Li Jia Jia Yan Guan Zonggen Peng Hongkai Bi Chunling Xiao Shan Cen Maoluo Gan |
author_sort |
Jiao Li |
title |
Broad-Spectrum Antiviral Natural Products from the Marine-Derived <em>Penicillium</em> sp. IMB17-046 |
title_short |
Broad-Spectrum Antiviral Natural Products from the Marine-Derived <em>Penicillium</em> sp. IMB17-046 |
title_full |
Broad-Spectrum Antiviral Natural Products from the Marine-Derived <em>Penicillium</em> sp. IMB17-046 |
title_fullStr |
Broad-Spectrum Antiviral Natural Products from the Marine-Derived <em>Penicillium</em> sp. IMB17-046 |
title_full_unstemmed |
Broad-Spectrum Antiviral Natural Products from the Marine-Derived <em>Penicillium</em> sp. IMB17-046 |
title_sort |
broad-spectrum antiviral natural products from the marine-derived <em>penicillium</em> sp. imb17-046 |
publisher |
MDPI AG |
series |
Molecules |
issn |
1420-3049 |
publishDate |
2019-08-01 |
description |
A new pyrazine derivative, trypilepyrazinol (<b>1</b>), a new α-pyrone polyketide, (+)-neocitreoviridin (<b>2</b>), and a new ergostane analogue, 3β-hydroxyergosta-8,14,24(28)-trien-7-one (<b>3</b>), were isolated and characterized along with five known compounds from the marine-derived fungus <i>Penicillium</i> sp. IMB17-046. The structures of these new compounds were determined using spectroscopic data analyses (HRESIMS, 1D- and 2D-NMR), X-ray crystallography analysis, and TDDFT ECD calculation. Compounds <b>1</b> and <b>3</b> exhibited broad-spectrum antiviral activities against different types of viruses, including human immunodeficiency virus (HIV), hepatitis C virus (HCV), and influenza A virus (IAV), with IC<sub>50</sub> values ranging from 0.5 to 7.7 μM. Compounds <b>1</b> and <b>2</b> showed antibacterial activities against <i>Helicobacter pylori</i>, a causative pathogen of various gastric diseases, with minimum inhibitory concentration (MIC) values of 1–16 μg/mL. |
topic |
marine fungus <i>Penicillium</i> pyrazine natural product antiviral HIV influenza A virus <i>Helicobacter pylori</i> |
url |
https://www.mdpi.com/1420-3049/24/15/2821 |
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