Methyl Mercapturate Synthesis: An Efficient, Convenient and Simple Method
A safe and simple method for methyl S-arylmercapturate synthesis is described. Thirteen such compounds, to be used afterwards in metabolism studies, have been obtained with yields ranging from 71 to 99.6%. These compounds were obtained using a sulfa-Michael addition and synthesized by adding the cor...
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| Format: | Article |
| Language: | English |
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MDPI AG
2008-10-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/13/10/2394/ |
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doaj-958347aefdb74473b09256030f414a842020-11-24T21:25:59ZengMDPI AGMolecules1420-30492008-10-01131023942407Methyl Mercapturate Synthesis: An Efficient, Convenient and Simple MethodManuella BurgartFrédéric CosnierBenoît CossecA safe and simple method for methyl S-arylmercapturate synthesis is described. Thirteen such compounds, to be used afterwards in metabolism studies, have been obtained with yields ranging from 71 to 99.6%. These compounds were obtained using a sulfa-Michael addition and synthesized by adding the corresponding thiophenols to a mixture composed of methyl 2-acetamidoacrylate (MAA), potassium carbonate and a phase transfer catalyst, Aliquat 336. MAA, the initial synthon, was itself isolated in quasi quantitative yield following a fully described synthesis.http://www.mdpi.com/1420-3049/13/10/2394/Mercapturic acidsSulfa-Michael additionPhase Transfer CatalysisBiomarker |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Manuella Burgart Frédéric Cosnier Benoît Cossec |
| spellingShingle |
Manuella Burgart Frédéric Cosnier Benoît Cossec Methyl Mercapturate Synthesis: An Efficient, Convenient and Simple Method Molecules Mercapturic acids Sulfa-Michael addition Phase Transfer Catalysis Biomarker |
| author_facet |
Manuella Burgart Frédéric Cosnier Benoît Cossec |
| author_sort |
Manuella Burgart |
| title |
Methyl Mercapturate Synthesis: An Efficient, Convenient and Simple Method |
| title_short |
Methyl Mercapturate Synthesis: An Efficient, Convenient and Simple Method |
| title_full |
Methyl Mercapturate Synthesis: An Efficient, Convenient and Simple Method |
| title_fullStr |
Methyl Mercapturate Synthesis: An Efficient, Convenient and Simple Method |
| title_full_unstemmed |
Methyl Mercapturate Synthesis: An Efficient, Convenient and Simple Method |
| title_sort |
methyl mercapturate synthesis: an efficient, convenient and simple method |
| publisher |
MDPI AG |
| series |
Molecules |
| issn |
1420-3049 |
| publishDate |
2008-10-01 |
| description |
A safe and simple method for methyl S-arylmercapturate synthesis is described. Thirteen such compounds, to be used afterwards in metabolism studies, have been obtained with yields ranging from 71 to 99.6%. These compounds were obtained using a sulfa-Michael addition and synthesized by adding the corresponding thiophenols to a mixture composed of methyl 2-acetamidoacrylate (MAA), potassium carbonate and a phase transfer catalyst, Aliquat 336. MAA, the initial synthon, was itself isolated in quasi quantitative yield following a fully described synthesis. |
| topic |
Mercapturic acids Sulfa-Michael addition Phase Transfer Catalysis Biomarker |
| url |
http://www.mdpi.com/1420-3049/13/10/2394/ |
| work_keys_str_mv |
AT manuellaburgart methylmercapturatesynthesisanefficientconvenientandsimplemethod AT fraƒadaƒariccosnier methylmercapturatesynthesisanefficientconvenientandsimplemethod AT benoaƒatcossec methylmercapturatesynthesisanefficientconvenientandsimplemethod |
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1725981673420488704 |