Clinical features of neonatal listeriosis in Taiwan: A hospital-based study

• Main Authors: Yu-Lin Tai, Hsin Chi, Nan-Chang Chiu, Chien-Yu Lin, Jia Lu Cheng, Chyong-Hsin Hsu, Jui-Hsing Chang, Daniel Tsung-Ning Huang, Ching-Ying Huang, Fu-Yuan Huang
• Format: Article
• Language: English
• Published: Elsevier 2020-12-01
• Series: Journal of Microbiology, Immunology and Infection
• Subjects: Listeria monocytogenes; Listeriosis; Neonatal sepsis; Pregnancy
• Online Access: http://www.sciencedirect.com/science/article/pii/S1684118219301070

Background: Neonatal listeriosis is a major cause of mortality in newborn; however, there is limited information about this disease in Taiwan. The aim of our study was to identify the outcome determinants, clinical features, and incidence of pregnancy-associated listeriosis, which includes both neonatal and maternal listeriosis. Methods: We retrospectively analyzed the medical records of neonatal and maternal patients with pregnancy-associated listeriosis at two hospitals in Taiwan from January 2000 to December 2018. Listeriosis was indicated by positive Listeria monocytogenes culture. Results: Our study examined 18 neonates and 19 mothers. The neonatal and fetal death rate was 24%. All five cases of fetal losses or neonatal deaths occurred before 29 weeks of gestational age. The annual incidence of confirmed neonatal listeriosis increased significantly from 0.94/10,000 neonatal inpatients in 2000–2011 to 5.45/10,000 neonatal inpatients in 2012–2018 (p = 0.026). Clinical presentations of neonatal listeriosis included respiratory distress (85%), leukocytosis or leukopenia (77%), bandemia (69%), thrombocytopenia (77%), hypocalcemia (100%) and elevated C-reactive protein (CRP) levels (92%). Lower gestation correlated with a higher fatality rate (p = 0.002). Among the maternal cases investigated, 67% had a diagnosis of listeriosis, and 72% presented with fever. However, only 21% of the 19 mothers received complete antepartum ampicillin treatment. Conclusions: The incidence of neonatal listeriosis is increasing, especially in preterm neonates. Maternal listeriosis should be adequately treated with appropriate empirical antibiotics.