miRNA in cardiac development and regeneration
Abstract Ischemic heart disease is one of the main causes of morbidity and mortality in the world. In adult mammalian hearts, most cardiomyocytes are terminally differentiated and have extremely limited capacity of proliferation, making it impossible to regenerate the heart after injuries such as my...
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doaj-958e13d96d384359914221133929d4f92021-06-06T11:27:35ZengSpringerOpenCell Regeneration2045-97692021-06-0110112110.1186/s13619-021-00077-5miRNA in cardiac development and regenerationZhaohui Ouyang0Ke Wei1Institute for Regenerative Medicine, Shanghai East Hospital, Shanghai Institute of Stem Cell Research and Clinical Translation, Shanghai Key Laboratory of Signaling and Disease Research, Frontier Science Center for Stem Cell Research, School of Life Sciences and Technology, Tongji UniversityInstitute for Regenerative Medicine, Shanghai East Hospital, Shanghai Institute of Stem Cell Research and Clinical Translation, Shanghai Key Laboratory of Signaling and Disease Research, Frontier Science Center for Stem Cell Research, School of Life Sciences and Technology, Tongji UniversityAbstract Ischemic heart disease is one of the main causes of morbidity and mortality in the world. In adult mammalian hearts, most cardiomyocytes are terminally differentiated and have extremely limited capacity of proliferation, making it impossible to regenerate the heart after injuries such as myocardial infarction. MicroRNAs (miRNAs), a class of non-coding single-stranded RNA, which are involved in mRNA silencing and the regulation of post-transcriptional gene expression, have been shown to play a crucial role in cardiac development and cardiomyocyte proliferation. Muscle specific miRNAs such as miR-1 are key regulators of cardiomyocyte maturation and growth, while miR-199-3p and other miRNAs display potent activity to induce proliferation of cardiomyocytes. Given their small size and relative pleiotropic effects, miRNAs have gained significant attraction as promising therapeutic targets or tools in cardiac regeneration. Increasing number of studies demonstrated that overexpression or inhibition of specific miRNAs could induce cardiomyocyte proliferation and cardiac regeneration. Some common targets of pro-proliferation miRNAs, such as the Hippo-Yap signaling pathway, were identified in multiple species, highlighting the power of miRNAs as probes to dissect core regulators of biological processes. A number of miRNAs have been shown to improve heart function after myocardial infarction in mice, and one trial in swine also demonstrated promising outcomes. However, technical difficulties, especially in delivery methods, and adverse effects, such as uncontrolled proliferation, remain. In this review, we summarize the recent progress in miRNA research in cardiac development and regeneration, examine the mechanisms of miRNA regulating cardiomyocyte proliferation, and discuss its potential as a new strategy for cardiac regeneration therapy.https://doi.org/10.1186/s13619-021-00077-5microRNAheartcardiomyocytedevelopmentproliferationregeneration |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Zhaohui Ouyang Ke Wei |
spellingShingle |
Zhaohui Ouyang Ke Wei miRNA in cardiac development and regeneration Cell Regeneration microRNA heart cardiomyocyte development proliferation regeneration |
author_facet |
Zhaohui Ouyang Ke Wei |
author_sort |
Zhaohui Ouyang |
title |
miRNA in cardiac development and regeneration |
title_short |
miRNA in cardiac development and regeneration |
title_full |
miRNA in cardiac development and regeneration |
title_fullStr |
miRNA in cardiac development and regeneration |
title_full_unstemmed |
miRNA in cardiac development and regeneration |
title_sort |
mirna in cardiac development and regeneration |
publisher |
SpringerOpen |
series |
Cell Regeneration |
issn |
2045-9769 |
publishDate |
2021-06-01 |
description |
Abstract Ischemic heart disease is one of the main causes of morbidity and mortality in the world. In adult mammalian hearts, most cardiomyocytes are terminally differentiated and have extremely limited capacity of proliferation, making it impossible to regenerate the heart after injuries such as myocardial infarction. MicroRNAs (miRNAs), a class of non-coding single-stranded RNA, which are involved in mRNA silencing and the regulation of post-transcriptional gene expression, have been shown to play a crucial role in cardiac development and cardiomyocyte proliferation. Muscle specific miRNAs such as miR-1 are key regulators of cardiomyocyte maturation and growth, while miR-199-3p and other miRNAs display potent activity to induce proliferation of cardiomyocytes. Given their small size and relative pleiotropic effects, miRNAs have gained significant attraction as promising therapeutic targets or tools in cardiac regeneration. Increasing number of studies demonstrated that overexpression or inhibition of specific miRNAs could induce cardiomyocyte proliferation and cardiac regeneration. Some common targets of pro-proliferation miRNAs, such as the Hippo-Yap signaling pathway, were identified in multiple species, highlighting the power of miRNAs as probes to dissect core regulators of biological processes. A number of miRNAs have been shown to improve heart function after myocardial infarction in mice, and one trial in swine also demonstrated promising outcomes. However, technical difficulties, especially in delivery methods, and adverse effects, such as uncontrolled proliferation, remain. In this review, we summarize the recent progress in miRNA research in cardiac development and regeneration, examine the mechanisms of miRNA regulating cardiomyocyte proliferation, and discuss its potential as a new strategy for cardiac regeneration therapy. |
topic |
microRNA heart cardiomyocyte development proliferation regeneration |
url |
https://doi.org/10.1186/s13619-021-00077-5 |
work_keys_str_mv |
AT zhaohuiouyang mirnaincardiacdevelopmentandregeneration AT kewei mirnaincardiacdevelopmentandregeneration |
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1721393982265622528 |